A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals

Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly injected into a pre-cooled vessel and sonicated at 4C. The resultant suspensions were characterized using a Zetasizer. The particle size, polydispersity index and Zeta potential were elucidated. Further characterization was undertaken using powder X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and energy dispersive X-ray spectroscopy scanning electron microscopy. Different surfactants were assessed for their ability to stabilize the nano co-crystals and for their ability to produce nano co-crystals with specific and desirable critical quality attributes (CQA) including particle size (PS) < 1000 nm, polydispersity index (PDI) < 0.500 and Zeta potential (ZP) < −30 mV. All surfactants produced co-crystals in the nanometer range. The PDI and PS are concentration-dependent for all nano co-crystals manufactured while only ZP was within specification when sodium dodecyl sulfate was used in the process.

Original languageEnglish
Article number182
JournalPharmaceutics
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2020
Externally publishedYes

Keywords

  • Crystal engineering
  • HIV/AIDS
  • Lamivudine
  • Nano co-crystals
  • Particle size
  • Polydispersity index
  • Sonochemistry
  • Zeta potential
  • Zidovudine

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