A More Sustainable Isocyanide Synthesis from N-Substituted Formamides Using Phosphorus Oxychloride in the Presence of Triethylamine as Solvent

Sodeeq Aderotimi Salami*, Xavier Siwe-Noundou, Rui Werner Maçedo Krause

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A simple, green, and highly efficient protocol for the synthesis of isocyanides is described. The reaction involves dehydration of formamides with phosphorus oxychloride in the presence of triethylamine as solvent at 0 °C. The product isocyanides were obtained in high to excellent yields in less than 5 min. The method offers several advantages including increased synthesis speed, relatively mild conditions, and rapid access to large numbers of functionalized isocyanides, excellent purity, increased safety, and minimal reaction waste. The new approach of synthesising dehydrative isocyanides from formamides is significantly more environmentally-friendly than prior methods.

Original languageEnglish
Article number6850
JournalMolecules
Volume27
Issue number20
DOIs
Publication statusPublished - Oct 2022
Externally publishedYes

Keywords

  • N-substituted formamides
  • green chemistry
  • isocyanides
  • phosphorus oxychloride

Fingerprint

Dive into the research topics of 'A More Sustainable Isocyanide Synthesis from N-Substituted Formamides Using Phosphorus Oxychloride in the Presence of Triethylamine as Solvent'. Together they form a unique fingerprint.

Cite this