TY - JOUR
T1 - A New Chalcone and Antimicrobial Chemical Constituents of Dracaena stedneuri
AU - Mouzié, Cédric M.
AU - Guefack, Michel Gael F.
AU - Kianfé, Boris Y.
AU - Serondo, Héritier U.
AU - Ponou, Beaudelaire K.
AU - Siwe-Noundou, Xavier
AU - Teponno, Rémy B.
AU - Krause, Rui W.M.
AU - Kuete, Victor
AU - Tapondjou, Léon A.
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - Microbial infections are leading causes of death and morbidity all over the world due to the development of the resistance to antibiotics by certain microorganisms. In this study, the chemical exploration of the ethanol (EtOH) extract of the aerial part of Dracaena stedneuri (Dracaenaceae) led to the isolation of one previously unreported chalcone derivative, i.e., 2′,4′-dihydroxy-2,3′-dimethoxychalcone (1), together with 12 known compounds: 8-(C)-methylquercetagetin-3,6,3′-trimethyl ether (2), methyl-galangine (3), quercetin (4), kaempferol (5), 6,8-dimethylchrysin (6), ombuine-3-O-rutinoside (4′,7-dimethylquercetin-3-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside) (7), alliospiroside A (8), β-sitosterol 3-O-glucopyranoside (9), ishigoside (10), betulinic acid (11), oleanolic acid (12), and lupeol (13). The structures were determined by spectroscopic and spectrometric analysis including 1-and 2-Dimensional Nuclear Magnetic Resonance (1D-and 2D-NMR), High-Resolution Electrospray Ion-ization Mass Spectrometry (HRESIMS), and comparison with literature data. The isolated secondary metabolites and crude extract displayed antibacterial activity against some multidrug-resistant strains with minimal inhibitory concentration (MIC) values ranging from 32 to 256 µg/mL. The antibacterial activity of compound 13 against Enterobacter aerogenes ATCC13048 (MIC value: 32 µg/mL) was higher than that of chloramphenicol used as the reference drug (MIC = 64 µg/mL).
AB - Microbial infections are leading causes of death and morbidity all over the world due to the development of the resistance to antibiotics by certain microorganisms. In this study, the chemical exploration of the ethanol (EtOH) extract of the aerial part of Dracaena stedneuri (Dracaenaceae) led to the isolation of one previously unreported chalcone derivative, i.e., 2′,4′-dihydroxy-2,3′-dimethoxychalcone (1), together with 12 known compounds: 8-(C)-methylquercetagetin-3,6,3′-trimethyl ether (2), methyl-galangine (3), quercetin (4), kaempferol (5), 6,8-dimethylchrysin (6), ombuine-3-O-rutinoside (4′,7-dimethylquercetin-3-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside) (7), alliospiroside A (8), β-sitosterol 3-O-glucopyranoside (9), ishigoside (10), betulinic acid (11), oleanolic acid (12), and lupeol (13). The structures were determined by spectroscopic and spectrometric analysis including 1-and 2-Dimensional Nuclear Magnetic Resonance (1D-and 2D-NMR), High-Resolution Electrospray Ion-ization Mass Spectrometry (HRESIMS), and comparison with literature data. The isolated secondary metabolites and crude extract displayed antibacterial activity against some multidrug-resistant strains with minimal inhibitory concentration (MIC) values ranging from 32 to 256 µg/mL. The antibacterial activity of compound 13 against Enterobacter aerogenes ATCC13048 (MIC value: 32 µg/mL) was higher than that of chloramphenicol used as the reference drug (MIC = 64 µg/mL).
KW - Dracaena steudneri
KW - antimicrobial activity
KW - chalcone
KW - dracaenaceae
UR - http://www.scopus.com/inward/record.url?scp=85132272668&partnerID=8YFLogxK
U2 - 10.3390/ph15060725
DO - 10.3390/ph15060725
M3 - Article
C2 - 35745644
AN - SCOPUS:85132272668
SN - 1424-8247
VL - 15
JO - Pharmaceuticals
JF - Pharmaceuticals
IS - 6
M1 - 725
ER -