A pilot study evaluating the prescribing of ceftriaxone in hospitals in Ghana: findings and implications

Daniel Kwame Afriyie, Seth Kwabena Amponsah, Justice Dogbey, Kwabena Agyekum, Samuel Kesse, Ilse Truter, Johanna C. Meyer, Brian Godman

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19 Citations (Scopus)


METHODS: A cross-sectional study to evaluate the appropriateness of ceftriaxone prescribing in a leading hospital in Ghana. Ceftriaxone prescribing in patient-record cards was assessed using a modified WHO drug-utilization evaluation criteria as well as referencing the national standard treatment guidelines in Ghana and the ceftriaxone package insert.

RESULTS: A total of 251 patients were assessed. Ceftriaxone was most commonly prescribed for comorbid malaria with bacterial infections, urinary tract infections, sepsis and gastroenteritis. The appropriateness of the indication was 86% (n = 218). The doses most prescribed were 1g (41%) and 2g (39%). Stat dose and once-daily dosage regimen constituted 51.4% and 84.5%, respectively. The most common duration of treatment was 1 (51.4%) and 2 days (35.1%). The overall appropriateness of prescribing was 93% against a pre-set threshold of 97%.

CONCLUSION: The appropriateness of ceftriaxone prescribing was high in this leading hospital in Ghana; however, there is room for improvement with targeted education initiatives, with further research planned.

BACKGROUND AND OBJECTIVES: Widespread empiric use of antibiotics exists especially in developing countries. This is a concern since inappropriate use of antibiotics, including their extended inappropriate use, will increase resistance rates. Consequently, there is a need to evaluate antibiotic utilisation across healthcare sectors to improve future use. This includes ceftriaxone, widely used among hospitals including those in Ghana.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalHospital Practice
Issue number4
Publication statusPublished - 1 Oct 2017
Externally publishedYes


  • Appropriateness
  • Ghana
  • ceftriaxone
  • drug use evaluation
  • thresholds


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