A review of vaccine research and development: Human enteric infections

Marc P. Girard*, Duncan Steele, Claire Lise Chaignat, Marie Paule Kieny

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

154 Citations (Scopus)

Abstract

Worldwide, enteric infections rank third among all causes of disease burden, being responsible for some 1.7-2.5 million deaths per year, mostly in young children and infants in developing countries. The main infectious agents responsible for human enteric infections include several viruses (enteric adenoviruses, astroviruses, human caliciviruses (HuCV), rotaviruses (RV)) and several bacterial agents, such as Campylobacter jejuni, a variety of pathogenic Escherichia coli strains including enterotoxigenic E. coli (ETEC), several Shigella species, various Salmonella strains including S. typhi and S. paratyphi, the agents of typhoid fever, and Vibrio cholerae, the agent of cholera. While effective vaccines are available at present against typhoid fever and cholera, no vaccine is available against illnesses caused by HuCV, Campylobacter, ETEC or the Shigellae. Rotavirus vaccines have had more success, although RV disease prevention suffered a major setback in 1999 with the withdrawal of a live simian-human reassortant RV vaccine less than a year after its introduction. New live oral RV vaccines have now been developed and are or should presently be ready for licensure. This article reviews the state of the art in vaccine R&D against human viral and bacterial enteric infections of public health importance.

Original languageEnglish
Pages (from-to)2732-2750
Number of pages19
JournalVaccine
Volume24
Issue number15
DOIs
Publication statusPublished - 5 Apr 2006
Externally publishedYes

Keywords

  • Calicivirus
  • Campylobacter
  • Cholera
  • Diarrhoeas
  • Dysentery
  • ETEC
  • Enterotoxigenic Escherichia coli
  • Gastroenteritis
  • Rotavirus
  • Salmonella
  • Shigella
  • Traveler's diarrhoea
  • Typhoid fever
  • Vaccines
  • Vibrio cholerae

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