TY - JOUR
T1 - Adverse effects of carbamazepine monotherapy among patients in Nigeria
T2 - A pilot study and implications
AU - Olusanya, Adedunni
AU - Ogunleye, Olayinka
AU - Godman, Brian
AU - Fadare, Joseph
AU - Danesi, Mustafa
N1 - Publisher Copyright:
© 2017 Future Medicine Ltd.
PY - 2017/1
Y1 - 2017/1
N2 - Aim: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. Methods: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. Results: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. Conclusion: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.
AB - Aim: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. Methods: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. Results: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. Conclusion: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.
KW - Adverse events
KW - Carbamazepine
KW - Epilepsy
KW - Nigeria
UR - http://www.scopus.com/inward/record.url?scp=85007357347&partnerID=8YFLogxK
U2 - 10.2217/cer-2016-0057
DO - 10.2217/cer-2016-0057
M3 - Article
C2 - 27936907
AN - SCOPUS:85007357347
SN - 2042-6305
VL - 6
SP - 33
EP - 42
JO - Journal of Comparative Effectiveness Research
JF - Journal of Comparative Effectiveness Research
IS - 1
ER -
