TY - JOUR
T1 - Antibacterial cyclopentenones from the coprophilous fungus Clonostachys pseudochroleuca
AU - Kapche, Annick B.F.
AU - Eckhardt, Paul
AU - Tchamgoue, Joseph
AU - Tsakem, Bienvenu
AU - Kuete, Jenifer R.N.
AU - Trucksess, Aron
AU - Njouonkou, André Ledoux
AU - Ponou, Beaudelaire K.
AU - Tapondjou, Léon A.
AU - Opatz, Till
AU - Kuete, Victor
AU - Kalscheuer, Rainer
AU - Kouam, Simeon F.
AU - Teponno, Rémy Bertrand
N1 - Publisher Copyright:
© 2025 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025
Y1 - 2025
N2 - The chemical study of the ethyl acetate soluble fraction from the ethyl acetate:methanol (1:1) extract of the culture of Clonostachys pseudochroleuca led to the isolation of a new cyclopentenone, (4S,5R) 4-benzoyl-3,4,5-trihydroxy-2-(4-hydroxyphenyl)cyclopent-2-en-1-one (2), along with the known phaseocyclopentenone A (1). Their structures were assigned on the basis of 1D and 2D NMR spectroscopy and HRESIMS data. The absolute configuration of the chiral centres was determined by Electronic Circular Dichroism (ECD) analysis. In the microdilution assay, the crude extract exhibited weak activity against Escherichia coli AG100 and Klebsiella pneumoniae 55 with MIC values of 256 µg/mL and 512 µg/mL, respectively. Compound 1 showed moderate activity against E. coli AG100 with an MIC of 64 µg/mL, while the new metabolite 2 exhibited moderate activity against Klebsiella pneumoniae ATCC11 with an MIC of 64 µg/mL.
AB - The chemical study of the ethyl acetate soluble fraction from the ethyl acetate:methanol (1:1) extract of the culture of Clonostachys pseudochroleuca led to the isolation of a new cyclopentenone, (4S,5R) 4-benzoyl-3,4,5-trihydroxy-2-(4-hydroxyphenyl)cyclopent-2-en-1-one (2), along with the known phaseocyclopentenone A (1). Their structures were assigned on the basis of 1D and 2D NMR spectroscopy and HRESIMS data. The absolute configuration of the chiral centres was determined by Electronic Circular Dichroism (ECD) analysis. In the microdilution assay, the crude extract exhibited weak activity against Escherichia coli AG100 and Klebsiella pneumoniae 55 with MIC values of 256 µg/mL and 512 µg/mL, respectively. Compound 1 showed moderate activity against E. coli AG100 with an MIC of 64 µg/mL, while the new metabolite 2 exhibited moderate activity against Klebsiella pneumoniae ATCC11 with an MIC of 64 µg/mL.
KW - Bionectriaceae
KW - Clonostachys pseudochroleuca
KW - antibacterial activity
KW - coprophilous fungi
KW - cyclopentenones
UR - https://www.scopus.com/pages/publications/105017503433
U2 - 10.1080/14786419.2025.2565818
DO - 10.1080/14786419.2025.2565818
M3 - Article
C2 - 41017548
AN - SCOPUS:105017503433
SN - 1478-6419
JO - Natural Product Research
JF - Natural Product Research
ER -
