Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

Mohsen Safaei; Farnoosh Khaleseh; Saba Ahmadi; Mohammad Salmani Mobarakeh; Douglas Law; Ling Shing Wong; D. Ravinder; Amos Nhlapo; Mohd Hashim; Azra Parveen

doi:10.14314/polimery.2025.3.4

Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

Mohsen Safaei, Farnoosh Khaleseh, Saba Ahmadi, Mohammad Salmani Mobarakeh, Douglas Law, Ling Shing Wong, D. Ravinder, Amos Nhlapo^*, Mohd Hashim, Azra Parveen

^*Corresponding author for this work

Medical Physics

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.

Original language	English
Pages (from-to)	186-193
Number of pages	8
Journal	Polimery
Volume	70
Issue number	3
DOIs	https://doi.org/10.14314/polimery.2025.3.4
Publication status	Published - 2025

Keywords

Streptococcus mutans
Taguchi method
human health
nanocomposite
poly(lactic-co-glycolic acid)
selenium

Access to Document

10.14314/polimery.2025.3.4

Cite this

@article{258ee97406174724b3a2a9c7a7c8c404,

title = "Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm",

abstract = "To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites{\textquoteright} structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.",

keywords = "Streptococcus mutans, Taguchi method, human health, nanocomposite, poly(lactic-co-glycolic acid), selenium",

author = "Mohsen Safaei and Farnoosh Khaleseh and Saba Ahmadi and Mobarakeh, \{Mohammad Salmani\} and Douglas Law and Wong, \{Ling Shing\} and D. Ravinder and Amos Nhlapo and Mohd Hashim and Azra Parveen",

year = "2025",

doi = "10.14314/polimery.2025.3.4",

language = "English",

volume = "70",

pages = "186--193",

journal = "Polimery",

issn = "0032-2725",

publisher = "Industrial Chemistry Research Institute",

number = "3",

}

TY - JOUR

T1 - Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

AU - Safaei, Mohsen

AU - Khaleseh, Farnoosh

AU - Ahmadi, Saba

AU - Mobarakeh, Mohammad Salmani

AU - Law, Douglas

AU - Wong, Ling Shing

AU - Ravinder, D.

AU - Nhlapo, Amos

AU - Hashim, Mohd

AU - Parveen, Azra

PY - 2025

Y1 - 2025

N2 - To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.

AB - To determine the optimal conditions for obtaining poly(lactic-co-glycolic) acid with selenium (PLGA/selenium) nanocomposites the Taguchi method was used. FT-IR, Raman spectroscopy, XRD and FESEM analysis confirmed the nanocomposites’ structure. The nanocomposite containing 6 mg/mL of selenium obtained in the process where the mixing time was 75 min showed the highest antibacterial activity against Streptococcus mutans. The obtained nanocomposites are an innovative approach to improving oral health and can be used as antibacterial materials for medical and dental applications.

KW - Streptococcus mutans

KW - Taguchi method

KW - human health

KW - nanocomposite

KW - poly(lactic-co-glycolic acid)

KW - selenium

UR - https://www.scopus.com/pages/publications/105001994614

U2 - 10.14314/polimery.2025.3.4

DO - 10.14314/polimery.2025.3.4

M3 - Article

AN - SCOPUS:105001994614

SN - 0032-2725

VL - 70

SP - 186

EP - 193

JO - Polimery

JF - Polimery

IS - 3

ER -

Antibacterial effect of polylactic-co-glycolic acid/selenium nanocomposite against dental biofilm

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this