TY - JOUR
T1 - Antioxidant and antidiabetic activities of flavonoid derivative compounds isolated from sclerocarya birrea leaves
AU - Ndwandwe, Sithembiso L.
AU - Olivier, Mutendela T.
AU - Gololo, Sechene S.
N1 - Publisher Copyright:
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PY - 2021/1
Y1 - 2021/1
N2 - Sclerocarya birrea is one of many medicinal plants used in African traditional medicine for treatment of diabetes. Bioassay-guided fractionation of the ethanolic crude extract of the leaves of the plant species led to the isolation of a pure compound (CMP-1). The pure compound showed antioxidant and antidiabetic activities with average IC50 values of 1.04 mg/mL and 46 µg/mL, respectively that were well comparable to the crude extract and known standards compounds, ascorbic acid and quercetin. The spectroscopic profiling of the purified compound revealed a flavonoid derivative structural skeleton. The findings of the study suggested that the flavonoid derivative compounds play a major role towards the medicinal value of Sclerocarya birrea.
AB - Sclerocarya birrea is one of many medicinal plants used in African traditional medicine for treatment of diabetes. Bioassay-guided fractionation of the ethanolic crude extract of the leaves of the plant species led to the isolation of a pure compound (CMP-1). The pure compound showed antioxidant and antidiabetic activities with average IC50 values of 1.04 mg/mL and 46 µg/mL, respectively that were well comparable to the crude extract and known standards compounds, ascorbic acid and quercetin. The spectroscopic profiling of the purified compound revealed a flavonoid derivative structural skeleton. The findings of the study suggested that the flavonoid derivative compounds play a major role towards the medicinal value of Sclerocarya birrea.
KW - Antidiabetic activity
KW - Antioxidant activity
KW - Flavonoid derivatives
KW - Sclerocarya birrea
UR - http://www.scopus.com/inward/record.url?scp=85098636855&partnerID=8YFLogxK
U2 - 10.14233/ajchem.2021.22909
DO - 10.14233/ajchem.2021.22909
M3 - Article
AN - SCOPUS:85098636855
SN - 0970-7077
VL - 33
SP - 57
EP - 61
JO - Asian Journal of Chemistry
JF - Asian Journal of Chemistry
IS - 1
ER -
