Antiplasmodial activity of the n-Hexane extract from pleurotus ostreatus (Jacq. ex. Fr) P. Kumm.

Ozadheoghene Eriarie Afieroho*, Xavier Siwe Noundou, Chiazor P. Onyia, Osamuyi H. Festus, Elizabeth C. Chukwu, Olutayo M. Adedokun, Michelle Isaacs, Heinrich C. Hoppe, Rui W.M. Krause, Kio A. Abo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objectives: Several mushrooms species have been reported to be nematophagous and antiprotozoan. This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus ostreatus and the isolation of a sterol from the extract. Materials and Methods: Antiplasmodial and cytotoxicity assays were done in vitro using the plasmodium lactate dehydrogenase assay and human HeLa cervical cell lines, respectively. The structure of the isolated compound from the n-hexane extract was elucidated using spectroscopic techniques. Results: The n-hexane extract (yield: 0.93% w/w) showed dose dependent antiplasmodial activity with the trend in parasite inhibition of: chloroquine (IC 50 =0.016 μg/mL) > n-hexane extract (IC 50 =25.18 μg/mL). It also showed mild cytotoxicity (IC 50 >100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC 50 =0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalTurkish Journal of Pharmaceutical Sciences
Issue number1
Publication statusPublished - Mar 2019
Externally publishedYes


  • Cytotoxicity
  • Ergosterol
  • Malaria
  • Nutraceuticals
  • Pleurotus ostreatus


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