Application of diode array detection for the identification of poisoning by traditional medicines

G. N. Foukaridis; G. L. Muntingh; E. Osuch

doi:10.1016/0378-8741(94)90029-9

Application of diode array detection for the identification of poisoning by traditional medicines

G. N. Foukaridis^*, G. L. Muntingh, E. Osuch

^*Corresponding author for this work

Pharmacology & Therapeutics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A large percentage of acute poisonings in black South Africans is due to traditional medicines and plants. The combination of isocratic high performance liquid chromatography (HPLC) with on line UV spectrum detection via a diode array configuration has been applied to the detection and identification of traditional medicines (and plants) in poisoned patients. Four standard isocratic systems are used. Combination of the retention times in the HPLC chromatogram and a comparison of the full spectra between 190-600 nm of the peaks obtained from extracted patient samples (urine or blood) with that of traditional medicine extracts (collected and stored in a reference data file) makes reliable identification possible. Such information could improve the quality of data accumulation and therapeutic strategies.

Original language	English
Pages (from-to)	135-146
Number of pages	12
Journal	Journal of Ethnopharmacology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/0378-8741(94)90029-9
Publication status	Published - Feb 1994

Keywords

Diode array detectors (DAD)
HPLC
Poisoning
Traditional medicines

Access to Document

10.1016/0378-8741(94)90029-9

Cite this

@article{24bc651a48744297ab9b5289a6f45544,

title = "Application of diode array detection for the identification of poisoning by traditional medicines",

abstract = "A large percentage of acute poisonings in black South Africans is due to traditional medicines and plants. The combination of isocratic high performance liquid chromatography (HPLC) with on line UV spectrum detection via a diode array configuration has been applied to the detection and identification of traditional medicines (and plants) in poisoned patients. Four standard isocratic systems are used. Combination of the retention times in the HPLC chromatogram and a comparison of the full spectra between 190-600 nm of the peaks obtained from extracted patient samples (urine or blood) with that of traditional medicine extracts (collected and stored in a reference data file) makes reliable identification possible. Such information could improve the quality of data accumulation and therapeutic strategies.",

keywords = "Diode array detectors (DAD), HPLC, Poisoning, Traditional medicines",

author = "Foukaridis, {G. N.} and Muntingh, {G. L.} and E. Osuch",

note = "Funding Information: We want to thank Sr Mathiba for the collection of the samplesf rom the traditional healers,M r Fata for the extractions,a nd the Departmento f Botany of the University of Pretoria for the botanical identification.T he initial part of this work was supportedb y a grantt o the department from the Medical ResearchC ouncil.",

year = "1994",

month = feb,

doi = "10.1016/0378-8741(94)90029-9",

language = "English",

volume = "41",

pages = "135--146",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Application of diode array detection for the identification of poisoning by traditional medicines

AU - Foukaridis, G. N.

AU - Muntingh, G. L.

AU - Osuch, E.

N1 - Funding Information: We want to thank Sr Mathiba for the collection of the samplesf rom the traditional healers,M r Fata for the extractions,a nd the Departmento f Botany of the University of Pretoria for the botanical identification.T he initial part of this work was supportedb y a grantt o the department from the Medical ResearchC ouncil.

PY - 1994/2

Y1 - 1994/2

N2 - A large percentage of acute poisonings in black South Africans is due to traditional medicines and plants. The combination of isocratic high performance liquid chromatography (HPLC) with on line UV spectrum detection via a diode array configuration has been applied to the detection and identification of traditional medicines (and plants) in poisoned patients. Four standard isocratic systems are used. Combination of the retention times in the HPLC chromatogram and a comparison of the full spectra between 190-600 nm of the peaks obtained from extracted patient samples (urine or blood) with that of traditional medicine extracts (collected and stored in a reference data file) makes reliable identification possible. Such information could improve the quality of data accumulation and therapeutic strategies.

AB - A large percentage of acute poisonings in black South Africans is due to traditional medicines and plants. The combination of isocratic high performance liquid chromatography (HPLC) with on line UV spectrum detection via a diode array configuration has been applied to the detection and identification of traditional medicines (and plants) in poisoned patients. Four standard isocratic systems are used. Combination of the retention times in the HPLC chromatogram and a comparison of the full spectra between 190-600 nm of the peaks obtained from extracted patient samples (urine or blood) with that of traditional medicine extracts (collected and stored in a reference data file) makes reliable identification possible. Such information could improve the quality of data accumulation and therapeutic strategies.

KW - Diode array detectors (DAD)

KW - HPLC

KW - Poisoning

KW - Traditional medicines

UR - http://www.scopus.com/inward/record.url?scp=0028223026&partnerID=8YFLogxK

U2 - 10.1016/0378-8741(94)90029-9

DO - 10.1016/0378-8741(94)90029-9

M3 - Article

C2 - 8176956

AN - SCOPUS:0028223026

SN - 0378-8741

VL - 41

SP - 135

EP - 146

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 3

ER -

Application of diode array detection for the identification of poisoning by traditional medicines

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this