Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe

Ioana D. Olaru*, Anne Meierkord, Brian Godman, Crispen Ngwenya, Felicity Fitzgerald, Vongai Dondo, Rashida A. Ferrand, Katharina Kranzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 − 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146–165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalJournal of Chemotherapy
Volume32
Issue number8
DOIs
Publication statusPublished - Dec 2020

Keywords

  • AMR
  • Antibiotic resistance
  • Antimicrobial consumption
  • Antimicrobial resistance
  • Antimicrobial stewardship
  • Children

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