Association of carboxyhemoglobin levels with peripheral arterial disease in chronic smokers managed at dr george mukhari academic hospital

Mashudu Nemukula*, Motetelo Alfred Mogale, Honey Bridget Mkhondo, Lizette Bekker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Chronic cigarette smokers (CCS) are known to have elevated levels of carboxyhemoglobin (COHb). However, it is not known whether increased levels of COHb are associated with endothelial dysfunction (ED), and therefore the development of peripheral arterial disease (PAD). The aim of the study was to investigate the association of blood COHb and plasma nitric oxide (NO) levels, and whether it is an independent risk factor in the development of PAD among CCS at Dr George Mukhari Academic Hospital (DGMAH). A sample of 120 CCS with PAD and a convenience sample of 100 CCS without PAD were recruited into the study. Blood COHb levels were measured using the ABL 90 FLEX CO-oximeter automated spectroscopy. Plasma nitric oxide (NO) levels were measure using ELISA. Logistic regression analysis was used to investigate the association of blood COHb and plasma NO with PAD. Blood COHb levels of CCS with PAD were significantly higher than those of CCS without PAD, and the NO levels of CCS with PAD were significantly lower than those of CCS without PAD. Although both the blood COHb and plasma NO in CCS were significantly associated with PAD in bivariate logistic analysis, only plasma NO was independently associated with PAD in multivariate logistic analysis. This finding is consistent with the hypothesis that COHb is a cause of arterial damage in PAD, leading to reduced NO, and therefore reduced arterial dilation.

Original languageEnglish
Article number5581
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number15
DOIs
Publication statusPublished - 1 Aug 2020

Keywords

  • Carboxyhemoglobin
  • Chronic cigarette smokers
  • Endothelial dysfunction
  • Nitric oxide
  • Peripheral arterial disease

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