Bioactive cyclopentenone derivatives from marine isolates of fungi

Zhile Feng, Alain S. Leutou, Guohua Yang, Viviane N. Nenkep, Xavier N. Siwe, Hong Dae Choi, Jung Sook Kang, Byeng Wha Son*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


As part of an effort to discover bioactive natural products from marine sources, we investigated the bioactive secondary metabolites from two marine isolates of the fungi, Trichoderma viride and Rhizopus stolonifer. Three cyclopentenones, myrothenones A (1) and B (2) and trichodenone A (3), were isolated from T. viride and two cyclopentenones, 2-bromomyrothenone B (4) and botrytinone (5), were isolated from R. stolonifer. The molecular structures and absolute stereochemistries of the cyclopentenones were determined from chemical and physicochemical evidence, including quantum chemistry calculations, X-ray analysis, and the circular dichroism (CD) exciton chirality method. Myrothenone A (1) displays tyrosinase inhibitory activity, with an IC50 value of 6.6 μM, and is therefore more active than the positive control, kojic acid.

Original languageEnglish
Pages (from-to)2345-2350
Number of pages6
JournalBulletin of the Korean Chemical Society
Issue number10
Publication statusPublished - Oct 2009
Externally publishedYes


  • Botrytinone
  • Cyclopentenone
  • Myrothenone
  • Rhizopus stolonifer
  • Trichoderma viride


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