Biocompatibility of biomaterials for nanoencapsulation: Current approaches

Bwalya A. Witika, Pedzisai A. Makoni, Scott K. Matafwali, Billy Chabalenge, Chiluba Mwila, Aubrey C. Kalungia, Christian I. Nkanga, Alain M. Bapolisi, Roderick B. Walker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Nanoencapsulation is an approach to circumvent shortcomings such as reduced bioavailability, undesirable side effects, frequent dosing and unpleasant organoleptic properties of conventional drug delivery systems. The process of nanoencapsulation involves the use of biomaterials such as surfactants and/or polymers, often in combination with charge inducers and/or ligands for targeting. The biomaterials selected for nanoencapsulation processes must be as biocompatible as possible. The type(s) of biomaterials used for different nanoencapsulation approaches are highlighted and their use and applicability with regard to haemo-and, histocompatibility, cytotoxicity, genotoxicity and carcinogenesis are discussed.

Original languageEnglish
Article number1649
Pages (from-to)1-40
Number of pages40
JournalNanomaterials
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2020
Externally publishedYes

Keywords

  • Biocompatibility
  • Cytotoxicity
  • Genotoxicity
  • Haemocompatibility
  • Histocompatibility
  • Liposomes
  • Micelles
  • Nanocrystals
  • Nanoencapsulation
  • Nanospheres
  • Polymers
  • Surfactants

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