Bioinspired Electrospun Chitosan–Based Materials for Tissue Regeneration

Teboho Clement Mokhena; Asanda Mtibe; Lerato Hlekelele; Amos Nhlapo; Katekani Shingange; Sivuyisiwe Mapukata; Antonio Benjamim Mapossa; Mokgaotsa Jonas Mochane; Eric Mathete; Ndivhuwo Shumbula; Odireleng Martin Ntwaeaborwa

doi:10.1155/adv/8830315

Bioinspired Electrospun Chitosan–Based Materials for Tissue Regeneration

Teboho Clement Mokhena
, Asanda Mtibe^*
, Lerato Hlekelele
, Amos Nhlapo
, Katekani Shingange
, Sivuyisiwe Mapukata
, Antonio Benjamim Mapossa
, Mokgaotsa Jonas Mochane
, Eric Mathete
, Ndivhuwo Shumbula
, Odireleng Martin Ntwaeaborwa

^*Corresponding author for this work

Medical Physics

Research output: Contribution to journal › Review article › peer-review

Abstract

Chitosan (CS) is a cationic biopolymer that has shown unique opportunities in tissue engineering. The well-defined geometry, porosity, easy processability, and antimicrobial and antifungal properties are particularly beneficial for tissue regeneration. This review outlines the progress made in the preparation of bioinspired electrospun CS for tissue regeneration. The article concentrates on bioinspired electrospun CS and CS-based composites which have appeared in a good number of publications in the literature and enriched the field of tissue engineering. It also highlights the upscaling of electrospun nanofibers with recent advanced technologies. Finally, the overall summary, challenges, and future perspective in tissue regeneration based on bioinspired CS and related composite materials is presented.

Original language	English
Article number	8830315
Journal	Advances in Polymer Technology
Volume	2026
Issue number	1
DOIs	https://doi.org/10.1155/adv/8830315
Publication status	Published - 2026

Keywords

biomimetic
chitosan
electrospinning
tissue regeneration

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10.1155/adv/8830315

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title = "Bioinspired Electrospun Chitosan{\textendash}Based Materials for Tissue Regeneration",

abstract = "Chitosan (CS) is a cationic biopolymer that has shown unique opportunities in tissue engineering. The well-defined geometry, porosity, easy processability, and antimicrobial and antifungal properties are particularly beneficial for tissue regeneration. This review outlines the progress made in the preparation of bioinspired electrospun CS for tissue regeneration. The article concentrates on bioinspired electrospun CS and CS-based composites which have appeared in a good number of publications in the literature and enriched the field of tissue engineering. It also highlights the upscaling of electrospun nanofibers with recent advanced technologies. Finally, the overall summary, challenges, and future perspective in tissue regeneration based on bioinspired CS and related composite materials is presented.",

keywords = "biomimetic, chitosan, electrospinning, tissue regeneration",

author = "Mokhena, \{Teboho Clement\} and Asanda Mtibe and Lerato Hlekelele and Amos Nhlapo and Katekani Shingange and Sivuyisiwe Mapukata and Mapossa, \{Antonio Benjamim\} and Mochane, \{Mokgaotsa Jonas\} and Eric Mathete and Ndivhuwo Shumbula and Ntwaeaborwa, \{Odireleng Martin\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2026 Teboho Clement Mokhena et al. Advances in Polymer Technology published by John Wiley \& Sons Ltd.",

year = "2026",

doi = "10.1155/adv/8830315",

language = "English",

volume = "2026",

journal = "Advances in Polymer Technology",

issn = "0730-6679",

publisher = "John Wiley and Sons Inc",

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TY - JOUR

T1 - Bioinspired Electrospun Chitosan–Based Materials for Tissue Regeneration

AU - Mokhena, Teboho Clement

AU - Mtibe, Asanda

AU - Hlekelele, Lerato

AU - Nhlapo, Amos

AU - Shingange, Katekani

AU - Mapukata, Sivuyisiwe

AU - Mapossa, Antonio Benjamim

AU - Mochane, Mokgaotsa Jonas

AU - Mathete, Eric

AU - Shumbula, Ndivhuwo

AU - Ntwaeaborwa, Odireleng Martin

PY - 2026

Y1 - 2026

N2 - Chitosan (CS) is a cationic biopolymer that has shown unique opportunities in tissue engineering. The well-defined geometry, porosity, easy processability, and antimicrobial and antifungal properties are particularly beneficial for tissue regeneration. This review outlines the progress made in the preparation of bioinspired electrospun CS for tissue regeneration. The article concentrates on bioinspired electrospun CS and CS-based composites which have appeared in a good number of publications in the literature and enriched the field of tissue engineering. It also highlights the upscaling of electrospun nanofibers with recent advanced technologies. Finally, the overall summary, challenges, and future perspective in tissue regeneration based on bioinspired CS and related composite materials is presented.

AB - Chitosan (CS) is a cationic biopolymer that has shown unique opportunities in tissue engineering. The well-defined geometry, porosity, easy processability, and antimicrobial and antifungal properties are particularly beneficial for tissue regeneration. This review outlines the progress made in the preparation of bioinspired electrospun CS for tissue regeneration. The article concentrates on bioinspired electrospun CS and CS-based composites which have appeared in a good number of publications in the literature and enriched the field of tissue engineering. It also highlights the upscaling of electrospun nanofibers with recent advanced technologies. Finally, the overall summary, challenges, and future perspective in tissue regeneration based on bioinspired CS and related composite materials is presented.

KW - biomimetic

KW - chitosan

KW - electrospinning

KW - tissue regeneration

UR - https://www.scopus.com/pages/publications/105040916408

U2 - 10.1155/adv/8830315

DO - 10.1155/adv/8830315

M3 - Review article

AN - SCOPUS:105040916408

SN - 0730-6679

VL - 2026

JO - Advances in Polymer Technology

JF - Advances in Polymer Technology

IS - 1

M1 - 8830315

ER -

Bioinspired Electrospun Chitosan–Based Materials for Tissue Regeneration

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Keywords

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