TY - JOUR
T1 - Biological activities of plant extracts from Ficus elastica and Selaginella vogelli
T2 - An antimalarial, antitrypanosomal and cytotoxity evaluation
AU - Mbosso Teinkela, Jean Emmanuel
AU - Siwe Noundou, Xavier
AU - Nguemfo, Edwige Laure
AU - Meyer, Franck
AU - Wintjens, Rene
AU - Isaacs, Michelle
AU - Mpondo Mpondo, Albert Emmanuel
AU - Hoppe, Heinrich C.
AU - Krause, Rui Werner Maçedo
AU - Azebaze, Anatole Guy Blaise
N1 - Publisher Copyright:
© 2017
PY - 2018/1
Y1 - 2018/1
N2 - The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Ficus elastica Roxb. ex Hornem. aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC50 value < 10 μg/mL. The extract of S. vogelii did not significantly reduce the viability of P. falciparum at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 μg/mL. In contrast, at the same concentration, the extract of F. elastica exhibited plasmodiacidal activity (IC50 value of 9.5 μg/mL) and trypanocidal (IC50 value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
AB - The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Ficus elastica Roxb. ex Hornem. aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC50 value < 10 μg/mL. The extract of S. vogelii did not significantly reduce the viability of P. falciparum at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 μg/mL. In contrast, at the same concentration, the extract of F. elastica exhibited plasmodiacidal activity (IC50 value of 9.5 μg/mL) and trypanocidal (IC50 value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.
KW - Antiplasmodial
KW - Antitrypanosomal
KW - Cytotoxicity
KW - Ficus elastica
KW - Selaginella vogelii
UR - http://www.scopus.com/inward/record.url?scp=85026324795&partnerID=8YFLogxK
U2 - 10.1016/j.sjbs.2017.07.002
DO - 10.1016/j.sjbs.2017.07.002
M3 - Article
AN - SCOPUS:85026324795
SN - 1319-562X
VL - 25
SP - 117
EP - 122
JO - Saudi Journal of Biological Sciences
JF - Saudi Journal of Biological Sciences
IS - 1
ER -