TY - JOUR
T1 - Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate
AU - Salami, Sodeeq Aderotimi
AU - Siwe-Noundou, Xavier
AU - Krause, Rui W.M.
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4–SiO2 ). All reactions were performed in refluxing triethyl orthoformate (65◦C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.
AB - In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4–SiO2 ). All reactions were performed in refluxing triethyl orthoformate (65◦C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.
KW - N-formylation
KW - amines
KW - immobilized sulfuric acid
KW - silica gel
KW - triethyl orthoformate
UR - http://www.scopus.com/inward/record.url?scp=85133458944&partnerID=8YFLogxK
U2 - 10.3390/molecules27134213
DO - 10.3390/molecules27134213
M3 - Article
C2 - 35807459
AN - SCOPUS:85133458944
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 13
M1 - 4213
ER -