Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate

Sodeeq Aderotimi Salami*, Xavier Siwe-Noundou, Rui W.M. Krause

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4–SiO2 ). All reactions were performed in refluxing triethyl orthoformate (65C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.

Original languageEnglish
Article number4213
JournalMolecules
Volume27
Issue number13
DOIs
Publication statusPublished - 1 Jul 2022
Externally publishedYes

Keywords

  • N-formylation
  • amines
  • immobilized sulfuric acid
  • silica gel
  • triethyl orthoformate

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