Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

Leigh P. Brody; Meliz Sahuri-Arisoylu; James R. Parkinson; Harry G. Parkes; Po Wah So; Nabil Hajji; Elouise Thomas; Gary S. Frost; Andrew D. Miller; Jimmy D. Bell

doi:10.2147/IJN.S135968

Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

Leigh P. Brody
, Meliz Sahuri-Arisoylu
, James R. Parkinson
, Harry G. Parkes
, Po Wah So
, Nabil Hajji
, Elouise Thomas
, Gary S. Frost
, Andrew D. Miller
, Jimmy D. Bell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.

Original language	English
Pages (from-to)	6677-6685
Number of pages	9
Journal	International Journal of Nanomedicine
Volume	12
DOIs	https://doi.org/10.2147/IJN.S135968
Publication status	Published - 8 Sept 2017
Externally published	Yes

Keywords

Cancer
Epigenetics
Lipid-based nanoparticles
Liposomes
Short-chain fatty acids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/IJN.S135968

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Brody, L. P., Sahuri-Arisoylu, M., Parkinson, J. R., Parkes, H. G., So, P. W., Hajji, N., Thomas, E., Frost, G. S., Miller, A. D., & Bell, J. D. (2017). Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine, 12, 6677-6685. https://doi.org/10.2147/IJN.S135968

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title = "Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects",

abstract = "Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.",

keywords = "Cancer, Epigenetics, Lipid-based nanoparticles, Liposomes, Short-chain fatty acids",

author = "Brody, \{Leigh P.\} and Meliz Sahuri-Arisoylu and Parkinson, \{James R.\} and Parkes, \{Harry G.\} and So, \{Po Wah\} and Nabil Hajji and Elouise Thomas and Frost, \{Gary S.\} and Miller, \{Andrew D.\} and Bell, \{Jimmy D.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Brody et al.",

year = "2017",

month = sep,

day = "8",

doi = "10.2147/IJN.S135968",

language = "English",

volume = "12",

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journal = "International Journal of Nanomedicine",

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T1 - Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

AU - Brody, Leigh P.

AU - Sahuri-Arisoylu, Meliz

AU - Parkinson, James R.

AU - Parkes, Harry G.

AU - So, Po Wah

AU - Hajji, Nabil

AU - Thomas, Elouise

AU - Frost, Gary S.

AU - Miller, Andrew D.

AU - Bell, Jimmy D.

PY - 2017/9/8

Y1 - 2017/9/8

N2 - Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.

AB - Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.

KW - Cancer

KW - Epigenetics

KW - Lipid-based nanoparticles

KW - Liposomes

KW - Short-chain fatty acids

UR - https://www.scopus.com/pages/publications/85029375143

U2 - 10.2147/IJN.S135968

DO - 10.2147/IJN.S135968

M3 - Article

C2 - 28932113

AN - SCOPUS:85029375143

SN - 1176-9114

VL - 12

SP - 6677

EP - 6685

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

ER -

Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

Abstract

Keywords

UN SDGs

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