Characterisation of rotavirus G9 strains isolated in the UK between 1995 and 1998

Miren Iturriza-Gómara, David Cubitt, Duncan Steele, Jonathan Green, David Brown, Gagandeep Kang, Ulrich Desselberger, Jim Gray*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

G9P[6] and G9P[8] rotavirus strains were identified during 1995/96 through the molecular epidemiological surveillance of rotavirus strains circulating in the UK between 1995 and 1998. An increase in the incidence and spread of sporadic infections with rotavirus genotype G9P[8] across the UK was detected in the two following seasons. Partial sequencing of the VP7 gene showed that all the UK strains shared a high degree of homology and were related very closely to G9 strains from the US and from symptomatic infections in India (≥96% homology). The UK strains were related more distantly to the apathogenic Indian strain 116E (85-87.8% homology). Phylogenetic analysis revealed clustering of the UK strains into 3 different lineages (I to III) and into two sub-lineages within lineage I. There were correlations between VP7 sequence clustering, the P type and the geographical origin of the G9 strains. Partial sequencing of the VP4 gene showed high degree of homology (>98%) among all the P[6] strains, and the sequences obtained from the P[8] strains clustered into 2 of the 3 global lineages described for P[8] strains associated with other G types. These data suggest that G9 strains may be a recent importation into the UK, and that G9P[8] strains may have emerged through reassortment in humans between G9P[6] strains introduced recently and the more prevalent cocirculating G1, G3 and G4 strains that normally carry VP4 genes of P[8] type. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)510-517
Number of pages8
JournalJournal of Medical Virology
Volume61
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Genotype
  • Phylogenetic analysis
  • Rotavirus
  • VP4
  • VP7

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