Chemotherapy- and radiotherapy-induced oral mucositis: pathobiology, epidemiology and management.

L. Feller*, R. Essop, N. H. Wood, R. A. Khammissa, U. M. Chikte, R. Meyerov, J. Lemmer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Oral mucositis is a debilitating complication of anticancer treatment, characterised by erythematous, atrophic, erosive or ulcerative lesions. Oral mucositis is almost always painful, affects eating, sleeping, and speech and affects the physiological and social well-being of the patient. The pathophysiology of the condition is not well understood. Guidelines to the treatment of oral mucositis are often contradictory so that there is no evidence based standard treatment protocol. Therefore the treatment is empiric. This paper offers a brief review of current knowledge of the pathophysiology and treatment of oral mucositis.

Original languageEnglish
Pages (from-to)372-374
Number of pages3
JournalSADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging
Issue number8
Publication statusPublished - 2010


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