Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study

Simon D. Taylor-Robinson*, E. Louise Thomas, Janet Sargentoni, Claude D. Marcus, Brian R. Davidson, Jimmy D. Bell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Human livers with histologically proven cirrhosis were assessed using in vitro 31P NMR spectroscopy. Spectra were compared with those from histologically normal livers and showed significant elevations in phosphoethanolamine (PE) and phosphocholine (PC) and significant reductions in glycerophosphorylethanolamine (GPE) and glycerophosphorylcholine (GPC). There were no significant differences in spectra from livers with compensated and decompensated cirrhosis. These results help to characterise the alterations in membrane metabolism in cirrhosis of the liver.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1272
Issue number2
DOIs
Publication statusPublished - 17 Oct 1995
Externally publishedYes

Keywords

  • Cirrhosis
  • Human
  • Liver
  • NMR, P
  • Phospholipid

Fingerprint

Dive into the research topics of 'Cirrhosis of the human liver: an in vitro 31P nuclear magnetic resonance study'. Together they form a unique fingerprint.

Cite this