Introduction: Cervical cancer is caused by persistent infection with high-risk human papilloma virus types. Screening is possible and has resulted in decreased incidence rates of cervical cancer by more than 50% from the mid 1970s to the mid 2000s in screened populations. Optimal screening options need to be identifi ed. Objectives: To compare the sensitivity of self-collected to healthcare worker (HCW) collected liquid based cytology (LBC) in detecting premalignant lesions, and to assess if self-collection with a tampon can be used as an additional sampling tool for cytology screening for cancer of the cervix. Method: A cross sectional descriptive study was conducted among women aged 18 years and older. Selfsampling consisted of ilex tampon use. The tampon was removed by a HCW and placed in a vial containing saline solution followed by subsequent pelvic examination using a speculum for collection of a endo-cervical sample using Cervarix brush placed in a PreserCyt solution. Both samples were sent for cytology analysis. A two-sided statistical test comparing HCW collected with self-collected samples. P-value of <0.05 was regarded as statistically signifi cant. Results: A total of 220 women were enrolled in the study. HCW collected LBC samples had more abnormal cervical lesions 50.9% vs self-collected samples of 19.5%. Women aged 30-49 had high prevalence of abnormal cervical lesions LSIL (22.7% vs 3.2%), HSIL (17.5% vs 3.8%) and ASCUS (10.4% vs 7.7%) in both HCW and self-collected samples respectively. There was 51.4% agreement between the two methods and a kappa score of 0.3 was obtained, which is an agreement that is fair. HCW collected samples had a sensitivity of 78.0% compared to 47.1 % of the self-collected samples for detection of pre-malignant lesions Conclusion: This study demonstrated a fair diagnostic correlation between self-sampling and HCW collected sampling for the diagnosis of premalignant cervical lesions. Self-sampling using the ilex tampon device had a low sensitivity in detecting premalignant lesions compared to doctor collected LBC samples.
|Number of pages||5|
|Journal||Obstetrics and Gynaecology Forum|
|Publication status||Published - 1 Jan 2022|
- cervical cancer
- liquid based cytology
- premalignant lesion