Composition of gut microbiota and its influence on the immunogenicity of oral rotavirus vaccines

Cliff A. Magwira*, Maureen B. Taylor

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

The introduction of oral rotavirus vaccines (ORVVs) has led to a reduction in number of hospitalisations and deaths due to rotavirus (RV) infection. However, the efficacy of the vaccines has been varied with low-income countries showing significantly lower efficacy as compared to high-income countries. The reasons for the disparity are not fully understood but are thought to be multi-factorial. In this review article, we discuss the concept that the disparity in the efficacy of oral rotavirus vaccines between the higher and lower socio-economical countries could be due the nature of the bacteria that colonises and establishes in the gut early in life. We further discuss recent studies that has demonstrated significant correlations between the composition of the gut bacteria and the immunogenicity of oral vaccines, and their implications in the development of novel oral RV vaccines or redesigning the current ones for maximum impact.

Original languageEnglish
Pages (from-to)3427-3433
Number of pages7
JournalVaccine
Volume36
Issue number24
DOIs
Publication statusPublished - 7 Jun 2018
Externally publishedYes

Keywords

  • Efficacy
  • Gut microbiota
  • Higher and lower socio-economic countries
  • Immunity
  • Immunogenicity
  • Oral rotavirus vaccine
  • Viral infection

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