Consensus Report on Shigella Controlled Human Infection Model: Introduction and Overview

Calman A. Maclennan*, Anastazia Older Aguilar, A. Duncan Steele

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In recent years, controlled human infection models (CHIMs) have become available for a range of infectious agents and have proved invaluable for understanding the disease process, pathogenesis, and mechanisms of immunity. CHIM studies have also contributed significantly to advancing development of a number of vaccines by providing an indication of vaccine efficacy. The Shigella CHIM has been established in 3 sites in the United States, and it is likely that the CHIM will play an important regulatory role for advancing the range of Shigella vaccine candidates that are currently in development. This supplement describes the harmonization of best practices across sites, with a view to maximizing the contribution that CHIM studies can make to Shigella vaccine development.

Original languageEnglish
Pages (from-to)S577-S579
JournalClinical Infectious Diseases
Volume69
DOIs
Publication statusPublished - 9 Dec 2019
Externally publishedYes

Keywords

  • Shigella
  • controlled human infection model
  • human infection studies

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