TY - JOUR
T1 - COVID-19 in an HIV-infected patient. Lessons learned from an autopsy case
AU - Khaba, Moshawa Calvin
AU - Ngale, Tshepo Cletus
AU - Madala, Nomandla
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - Despite measures put in place to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across South Africa, there has been a rapid spread which caused extensive morbidity and mortality. Whilst there is currently increased COVID-19 associated death, autopsies on COVID positive individuals are not routinely performed. An autopsy was performed on a 19 years old African patient who was recently diagnosed with human immunodeficiency virus (HIV). He presented with clinical features suggestive of SARS-CoV-2, which he subsequently tested positive for. Important histopathological findings included diffuse alveolar damage and fibrin thrombi. No superimposed infections were noted. The cause of death was attributed to COVID-19. We report the first autopsy case of an HIV-infected individual with COVID-19 as the cause of death.
AB - Despite measures put in place to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across South Africa, there has been a rapid spread which caused extensive morbidity and mortality. Whilst there is currently increased COVID-19 associated death, autopsies on COVID positive individuals are not routinely performed. An autopsy was performed on a 19 years old African patient who was recently diagnosed with human immunodeficiency virus (HIV). He presented with clinical features suggestive of SARS-CoV-2, which he subsequently tested positive for. Important histopathological findings included diffuse alveolar damage and fibrin thrombi. No superimposed infections were noted. The cause of death was attributed to COVID-19. We report the first autopsy case of an HIV-infected individual with COVID-19 as the cause of death.
KW - Autopsy
KW - COVID-19
KW - Diffuse alveolar damage
KW - Fibrin thrombi
KW - Human immunodeficiency virus (HIV)
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85096217167&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2020.09.1435
DO - 10.1016/j.ijid.2020.09.1435
M3 - Article
C2 - 32987179
AN - SCOPUS:85096217167
SN - 1201-9712
VL - 101
SP - 243
EP - 246
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -