Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

Bwalya A. Witika*, Kokoette E. Bassey, Patrick H. Demana, Xavier Siwe-Noundou, Madan S. Poka

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Development of nanomaterials for drug delivery has received considerable attention due to their potential for achieving on-target delivery to the diseased area while the surrounding healthy tissue is spared. Safe and efficiently delivered payloads have always been a challenge in pharmaceutics. Niosomes are self-assembled vesicular nanocarriers formed by hydration of a non-ionic surfactant, cholesterol or other molecules that combine to form a versatile drug delivery system with a variety of applications ranging from topical delivery to targeted delivery. Niosomes have advantages similar to those of liposomes with regards to their ability to incorporate both hydrophilic and hydrophobic payloads. Moreover, niosomes have simple manufacturing methods, low production cost and exhibit extended stability, consequently overcoming the major drawbacks associated with liposomes. This review provides a comprehensive summary of niosomal research to date, including the types of niosomes and critical material attributes (CMA) and critical process parameters (CPP) of niosomes and their effects on the critical quality attributes (CQA) of the technology. Furthermore, physical characterisation techniques of niosomes are provided. The review then highlights recent applications of specialised niosomes in drug delivery. Finally, limitations and prospects for this technology are discussed.

Original languageEnglish
Article number9668
JournalInternational Journal of Molecular Sciences
Volume23
Issue number17
DOIs
Publication statusPublished - Sep 2022

Keywords

  • immuno-niosomes
  • magnetic niosomes
  • pH-sensitive niosomes
  • targeted drug delivery
  • thermoresponsive niosomes

Fingerprint

Dive into the research topics of 'Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications'. Together they form a unique fingerprint.

Cite this