Cytotoxic and Antibacterial Activity of Selected Medicinal Plants used in South African Traditional Medicine

M. A. Makhafola, L. Middleton, M. T. Olivier*, O. O. Olaokun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Five plants were investigated for their antibacterial and cytotoxicity activities, namely: Lantana rugosa, Lippia javanica, Lippia wilmsii, Hilliardiella elaeagnoides and Withania somnifera. Four organisms and liver cells were used to evaluate the efficacy and the safety of the extracts from these plants. All the extracts showed antibacterial activity with the MIC ranging from 0.04 ± 0.04 mg/mL to 11.46 ± 9.66 mg/mL. The acetonic extract of L. javanica exhibited the highest antibacterial activity with MIC value of 0.04 ± 0.04 mg/mL against P. aeruginosa and 0.28 ± 0.35 mg/mL against S. aureus. Aqueous and acetonic extracts of L. wilmsii (LC50 > 1000 µg/mL) and the hexane extract of L. javanica (LC50 > 1000 µg/mL) were the least cytotoxic. While acetonic extract of L. javanica (0.01 ± 0.64 µg/mL) and hexane extract of L. wilmsii (0.03 ± 0.31 µg/mL) were the most cytotoxic.

Original languageEnglish
Pages (from-to)2623-2627
Number of pages5
JournalAsian Journal of Chemistry
Volume31
Issue number11
DOIs
Publication statusPublished - 2019

Keywords

  • Antibacterial activity
  • Cytotoxicity
  • Hilliardiella elaeagnoides
  • Lantana rugosa
  • Lippia javanica
  • Lippia wilmsii
  • Withania somnifera

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