Deep eutectic solvents for solid pesticide dosage forms

Justin Phillips, Walter W. Focke*, Elizabeth L. du Toit, James Wesley-Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

Original languageEnglish
Article number20729
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 2020
Externally publishedYes

Fingerprint

Dive into the research topics of 'Deep eutectic solvents for solid pesticide dosage forms'. Together they form a unique fingerprint.

Cite this