Deep eutectic solvents for solid pesticide dosage forms

Justin Phillips; Walter W. Focke; Elizabeth L. du Toit; James Wesley-Smith

doi:10.1038/s41598-020-77559-0

Deep eutectic solvents for solid pesticide dosage forms

Justin Phillips, Walter W. Focke^*, Elizabeth L. du Toit, James Wesley-Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

Original language	English
Article number	20729
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-77559-0
Publication status	Published - Dec 2020
Externally published	Yes

Access to Document

10.1038/s41598-020-77559-0

Cite this

@article{d718088679914786a83d173bac1da425,

title = "Deep eutectic solvents for solid pesticide dosage forms",

abstract = "Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.",

author = "Justin Phillips and Focke, {Walter W.} and {du Toit}, {Elizabeth L.} and James Wesley-Smith",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

doi = "10.1038/s41598-020-77559-0",

language = "English",

volume = "10",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Deep eutectic solvents for solid pesticide dosage forms

AU - Phillips, Justin

AU - Focke, Walter W.

AU - du Toit, Elizabeth L.

AU - Wesley-Smith, James

PY - 2020/12

Y1 - 2020/12

N2 - Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

AB - Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

UR - http://www.scopus.com/inward/record.url?scp=85096690059&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-77559-0

DO - 10.1038/s41598-020-77559-0

M3 - Article

C2 - 33244109

AN - SCOPUS:85096690059

SN - 2045-2322

VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 20729

ER -

Deep eutectic solvents for solid pesticide dosage forms

Abstract

Access to Document

Other files and links

Fingerprint

Cite this