Development and application of a membrane assisted solvent extraction-molecularly imprinted polymer based passive sampler for monitoring of selected pharmaceuticals in surface water

Sinegugu Khulu, Somandla Ncube, Yannick Nuapia, Lawrence Mzukisi Madikizela, Elizabeth Mavhunga, Luke Chimuka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we demonstrate the development, evaluation and pre-liminary application of a novel passive sampler for monitoring of selected pharmaceuticals in environmental waters. The samplers were calibrated in laboratory-based experiments to obtain sampling rates (Rs) for carbamazepine, methocarbamol, etilefrine, venlafaxine and nevirapine. Passive sampling was based on the diffusion of the target pharmaceuticals from surface water through a membrane bag which housed an ionic liquid as a green receiving solvent and a molecularly imprinted polymer. Effects of biofouling, deployment time and solvent type for the receiver phase were optimized for selective uptake of analytes in surface water. Notably, there was a decrease in the uptake of selected pharmaceuticals and consequently a decrease in their sampling rates in the presence of biofouling. The optimum matrix-matched sampling rates ranged from 0.0007 - 0.0018 L d−1 whilst the method detection and quantification limits ranged from 2.45 - 3.26 ng L−1 and 8.06 - 10.81 ng L−1, respectively. The optimized passive sampler was deployed in a dam situated in the heart of a typical highly populated township in the Gauteng Province of South Africa. Only etilefrine and methocarbamol were detected and quantified at maximum time weighted average concentrations of 12.88 and 72.29 ng L−1, respectively.

Original languageEnglish
Article number119145
JournalWater Research
Volume225
DOIs
Publication statusPublished - 15 Oct 2022
Externally publishedYes

Keywords

  • Aliquat 336
  • Environmental monitoring
  • Membrane assisted solvent extraction
  • Molecularly imprinted polymer
  • Passive sampling
  • Pharmaceuticals

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