TY - JOUR
T1 - Dextrin Nanocomposites as Matrices for Solid Dosage Forms
AU - Phillips, Justin
AU - Venter, Jaco Louis
AU - Atanasova, Maria
AU - Wesley-Smith, James
AU - Oosthuizen, Hester
AU - Emmambux, M. Naushad
AU - Du Toit, Elizabeth L.
AU - Focke, Walter W.
N1 - Funding Information:
Financial support for authors J.P. and H.O. from PAMSA and the Department of Science and Innovation under Grant DST/CON 0004/2019 is gratefully acknowledged. The authors also thank Jan Mentz and Greenfield Additives for kindly donating the hydrocalumite grade B44 sample, the layered double hydroxide (LDH) used in this study.
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/4/8
Y1 - 2020/4/8
N2 - Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure.
AB - Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure.
KW - acaricide, themoplastic starch
KW - cellulose nanofibers
KW - dextrin
KW - layered double hydroxide, solid dosage form
UR - http://www.scopus.com/inward/record.url?scp=85083084527&partnerID=8YFLogxK
U2 - 10.1021/acsami.0c02061
DO - 10.1021/acsami.0c02061
M3 - Article
C2 - 32191427
AN - SCOPUS:85083084527
VL - 12
SP - 16969
EP - 16977
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 14
ER -