Di(2-ethylhexyl)phthalate and type 2 diabetes

Sebolaishi Doris Makhubela; Ananias Hodi Kgopa; Matlou Phineas Mokgotho; Leshweni Jerry Shai

doi:10.1039/d4va00121d

Di(2-ethylhexyl)phthalate and type 2 diabetes

Sebolaishi Doris Makhubela^*, Ananias Hodi Kgopa, Matlou Phineas Mokgotho, Leshweni Jerry Shai

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The prevalence of type 2 diabetes is escalating worldwide and it has been suggested that exposure to endocrine disrupting chemicals, such as phthalates, contributes to the alarming increase. Di(2-ethylhexyl)phthalate (DEHP) is used as a plasticizer in a variety of everyday products; thus humans are constantly exposed to it. Animal studies have associated DEHP with adverse health effects such as reproduction and developmental toxicity, carcinogenicity and metabolic disruption. Concerns over the potential for similar adverse effects in humans are mounting. Recent reviews have reported the link between exposure to a broad set of phthalates and diabetes as well as diabetes-related metabolic conditions. This review evaluates the available information in the literature regarding the association between DEHP exposure and type 2 diabetes and related metabolic conditions, specifically insulin resistance and obesity.

Original language	English
Pages (from-to)	1679-1697
Number of pages	19
Journal	Environmental Science: Advances
Volume	3
Issue number	12
DOIs	https://doi.org/10.1039/d4va00121d
Publication status	Published - 15 Oct 2024

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10.1039/d4va00121d

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title = "Di(2-ethylhexyl)phthalate and type 2 diabetes",

abstract = "The prevalence of type 2 diabetes is escalating worldwide and it has been suggested that exposure to endocrine disrupting chemicals, such as phthalates, contributes to the alarming increase. Di(2-ethylhexyl)phthalate (DEHP) is used as a plasticizer in a variety of everyday products; thus humans are constantly exposed to it. Animal studies have associated DEHP with adverse health effects such as reproduction and developmental toxicity, carcinogenicity and metabolic disruption. Concerns over the potential for similar adverse effects in humans are mounting. Recent reviews have reported the link between exposure to a broad set of phthalates and diabetes as well as diabetes-related metabolic conditions. This review evaluates the available information in the literature regarding the association between DEHP exposure and type 2 diabetes and related metabolic conditions, specifically insulin resistance and obesity.",

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AU - Makhubela, Sebolaishi Doris

AU - Kgopa, Ananias Hodi

AU - Mokgotho, Matlou Phineas

AU - Shai, Leshweni Jerry

PY - 2024/10/15

Y1 - 2024/10/15

N2 - The prevalence of type 2 diabetes is escalating worldwide and it has been suggested that exposure to endocrine disrupting chemicals, such as phthalates, contributes to the alarming increase. Di(2-ethylhexyl)phthalate (DEHP) is used as a plasticizer in a variety of everyday products; thus humans are constantly exposed to it. Animal studies have associated DEHP with adverse health effects such as reproduction and developmental toxicity, carcinogenicity and metabolic disruption. Concerns over the potential for similar adverse effects in humans are mounting. Recent reviews have reported the link between exposure to a broad set of phthalates and diabetes as well as diabetes-related metabolic conditions. This review evaluates the available information in the literature regarding the association between DEHP exposure and type 2 diabetes and related metabolic conditions, specifically insulin resistance and obesity.

AB - The prevalence of type 2 diabetes is escalating worldwide and it has been suggested that exposure to endocrine disrupting chemicals, such as phthalates, contributes to the alarming increase. Di(2-ethylhexyl)phthalate (DEHP) is used as a plasticizer in a variety of everyday products; thus humans are constantly exposed to it. Animal studies have associated DEHP with adverse health effects such as reproduction and developmental toxicity, carcinogenicity and metabolic disruption. Concerns over the potential for similar adverse effects in humans are mounting. Recent reviews have reported the link between exposure to a broad set of phthalates and diabetes as well as diabetes-related metabolic conditions. This review evaluates the available information in the literature regarding the association between DEHP exposure and type 2 diabetes and related metabolic conditions, specifically insulin resistance and obesity.

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Di(2-ethylhexyl)phthalate and type 2 diabetes

Abstract

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