TY - JOUR
T1 - Discoid lupus erythematosus-related squamous cell carcinoma of the lip in an HIV-seropositive black male
AU - Molomo, Edward M.
AU - Bouckaert, Michael
AU - Khammissa, Razia A.G.
AU - Motswaledi, Hendrick M.
AU - Lemmer, Johan
AU - Feller, Liviu
N1 - Publisher Copyright:
© 2015 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Discoid lupus erythematosus (DLE) is an autoimmune disease commonly affecting sun-exposed areas of the skin. Subjects with DLE have high-levels of plasmacytoid dendritic cells -derived interferon-a, which mediates both loss of immune tolerance to self-antigens and exaggerated inflammatory state, and supports proliferation and differentiation of hyperactive B-cells. In a few cases, DLE of the lips, scalp, ears or nose may eventually progress to squamous cell carcinoma (SCC). Photosensitivity and the long-standing immune-mediated chronic inflammation and dysregulated healing characterized by atrophy, hypopigmentation or scarring inherent to DLE are risk factors for progression to SCC. We review some aspects of the pathogenesis of DLE and the possible roles of inflammation and photosensitivity in the carcinomatous transformation of DLE keratinocytes, and present an illustrative case of DLE of the lower lip in an HIV-tuberculosis co-infected black person, that progressed to SCC.
AB - Discoid lupus erythematosus (DLE) is an autoimmune disease commonly affecting sun-exposed areas of the skin. Subjects with DLE have high-levels of plasmacytoid dendritic cells -derived interferon-a, which mediates both loss of immune tolerance to self-antigens and exaggerated inflammatory state, and supports proliferation and differentiation of hyperactive B-cells. In a few cases, DLE of the lips, scalp, ears or nose may eventually progress to squamous cell carcinoma (SCC). Photosensitivity and the long-standing immune-mediated chronic inflammation and dysregulated healing characterized by atrophy, hypopigmentation or scarring inherent to DLE are risk factors for progression to SCC. We review some aspects of the pathogenesis of DLE and the possible roles of inflammation and photosensitivity in the carcinomatous transformation of DLE keratinocytes, and present an illustrative case of DLE of the lower lip in an HIV-tuberculosis co-infected black person, that progressed to SCC.
KW - Discoid lupus erythematosus-related inflammation
KW - discoid lupus erythematosus-related scarring
KW - squamous cell carcinoma of the lip
UR - http://www.scopus.com/inward/record.url?scp=84959519941&partnerID=8YFLogxK
U2 - 10.4103/0973-1482.146107
DO - 10.4103/0973-1482.146107
M3 - Article
C2 - 26881641
AN - SCOPUS:84959519941
SN - 0973-1482
VL - 11
SP - 1223
EP - 1225
JO - Journal of Cancer Research and Therapeutics
JF - Journal of Cancer Research and Therapeutics
IS - 4
ER -