Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action

Andrew D. Steele; Guillaume Ernouf; Young Eun Lee; William M. Wuest

doi:10.1021/acs.orglett.8b00054

Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action

Andrew D. Steele, Guillaume Ernouf, Young Eun Lee, William M. Wuest^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

Original language	English
Pages (from-to)	1126-1129
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.8b00054
Publication status	Published - 16 Feb 2018
Externally published	Yes

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title = "Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action",

abstract = "The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.",

author = "Steele, {Andrew D.} and Guillaume Ernouf and Lee, {Young Eun} and Wuest, {William M.}",

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AU - Steele, Andrew D.

AU - Ernouf, Guillaume

AU - Lee, Young Eun

AU - Wuest, William M.

PY - 2018/2/16

Y1 - 2018/2/16

N2 - The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

AB - The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

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U2 - 10.1021/acs.orglett.8b00054

DO - 10.1021/acs.orglett.8b00054

M3 - Article

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AN - SCOPUS:85042197729

SN - 1523-7060

VL - 20

SP - 1126

EP - 1129

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action

Abstract

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