Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action

Andrew D. Steele, Guillaume Ernouf, Young Eun Lee, William M. Wuest*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

Original languageEnglish
Pages (from-to)1126-1129
Number of pages4
JournalOrganic Letters
Volume20
Issue number4
DOIs
Publication statusPublished - 16 Feb 2018
Externally publishedYes

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