TY - JOUR
T1 - Doxorubicin-Based Hybrid Compounds as Potential Anticancer Agents
T2 - A Review
AU - Peter, Sijongesonke
AU - Alven, Sibusiso
AU - Maseko, Rejoice Bethusile
AU - Aderibigbe, Blessing Atim
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/7
Y1 - 2022/7
N2 - The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide. Doxorubicin, an anticancer agent, is currently used to treat several types of cancer. It disrupts myriad processes such as histone eviction, ceramide overproduction, DNA-adduct formation, reactive oxygen species generation, Ca2+, and iron hemostasis regulation. However, its use is limited by factors such as drug resistance, toxicity, and congestive heart failure reported in some patients. The combination of doxorubicin with other chemotherapeutic agents has been reported as an effective treatment option for cancer with few side effects. Thus, the hybridization of doxorubicin and other chemotherapeutic drugs is regarded as a promising approach that can lead to effective anticancer agents. This review gives an update on hybrid compounds containing the scaffolds of doxorubicin and its derivatives with potent chemotherapeutic effects.
AB - The scarcity of novel and effective therapeutics for the treatment of cancer is a pressing and alarming issue that needs to be prioritized. The number of cancer cases and deaths are increasing at a rapid rate worldwide. Doxorubicin, an anticancer agent, is currently used to treat several types of cancer. It disrupts myriad processes such as histone eviction, ceramide overproduction, DNA-adduct formation, reactive oxygen species generation, Ca2+, and iron hemostasis regulation. However, its use is limited by factors such as drug resistance, toxicity, and congestive heart failure reported in some patients. The combination of doxorubicin with other chemotherapeutic agents has been reported as an effective treatment option for cancer with few side effects. Thus, the hybridization of doxorubicin and other chemotherapeutic drugs is regarded as a promising approach that can lead to effective anticancer agents. This review gives an update on hybrid compounds containing the scaffolds of doxorubicin and its derivatives with potent chemotherapeutic effects.
KW - cancer
KW - chemotherapeutic drugs
KW - doxorubicin
KW - drug resistance
KW - drug toxicity
KW - hybrid compounds
UR - http://www.scopus.com/inward/record.url?scp=85135107364&partnerID=8YFLogxK
U2 - 10.3390/molecules27144478
DO - 10.3390/molecules27144478
M3 - Review article
C2 - 35889350
AN - SCOPUS:85135107364
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 14
M1 - 4478
ER -
