Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen

E. Green, C. L. Obi, M. Nchabeleng, B. E. de Villiers, P. P. Sein, T. Letsoalo, A. A. Hoosen, P. O. Bessong, R. N. Ndip*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Multidrug-resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. The prevalence of drug resistance in Mycobacterium tuberculosis (MTB) isolates (n=692) from Mpumalanga province was assessed. In total, 692 (64%) MTB strains from cases with pulmonary TB were tested for susceptibility against rifampicin, isoniazid, ethambutol, and streptomycin using the MGIT 960 instrument. Two hundred and nine (30.2%) strains were resistant to one or more drugs. Resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. The prevalence of MDR-TB ranged from 6.7% for three drugs to 34% for four drugs, with significant predictors being patients' age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). The result showed a high level (58.4%) of MDR-TB from cases in Mpumalanga province. To achieve a higher cure rate in this province, drug-susceptibility tests must be done for every case.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalJournal of Health, Population and Nutrition
Volume28
Issue number1
Publication statusPublished - Feb 2010
Externally publishedYes

Keywords

  • Drug resistance
  • Microbial
  • Mycobacterium tuberculosis
  • Risk factors
  • South Africa
  • Tuberculosis

Fingerprint

Dive into the research topics of 'Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province, South Africa: Possible Guiding Design of Retreatment Regimen'. Together they form a unique fingerprint.

Cite this