Early Wave Reflection and Pulse Wave Velocity Are Associated with Diastolic Dysfunction in Rheumatoid Arthritis

Lebogang Mokotedi; Sulé Gunter; Chanel Robinson; Frederic Michel; Ahmed Solomon; Gavin R Norton; Angela J Woodiwiss; Linda Tsang; Patrick H Dessein; Aletta M E Millen

doi:10.1007/s12265-019-09892-3

Early Wave Reflection and Pulse Wave Velocity Are Associated with Diastolic Dysfunction in Rheumatoid Arthritis

Lebogang Mokotedi, Sulé Gunter, Chanel Robinson, Frederic Michel, Ahmed Solomon, Gavin R Norton, Angela J Woodiwiss, Linda Tsang, Patrick H Dessein, Aletta M E Millen

Physiology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) impacts arterial and diastolic function. This study examined whether arterial properties can determine diastolic function in RA. In 173 RA patients, arterial function measures including carotid femoral pulse wave velocity (PWV), central systolic and pulse pressure, pulse pressure amplification, and the magnitude and timing of the forward and reflected waves were measured using applanation tonometry. Diastolic function parameters including the ratio of early-to-late transmitral velocity (E/A) and ratio of E to the mean of the lateral and septal wall myocardial tissue lengthening (e') were measured using echocardiography. The timing of the reflected wave was associated with E/A; PWV was related to E/e'. The timing of the reflected wave, forward wave magnitude, and pulse pressure amplification were associated with impaired relaxation; PWV was related to increased left ventricular (LV) filling pressure. Early wave reflection and PWV are associated with LV-impaired relaxation and increased filling pressure, respectively, in RA.

Original language	English
Pages (from-to)	580-590
Number of pages	11
Journal	Journal of Cardiovascular Translational Research
Volume	12
Issue number	6
DOIs	https://doi.org/10.1007/s12265-019-09892-3
Publication status	Published - Dec 2019

Keywords

Aged
Arthritis, Rheumatoid/complications
Carotid-Femoral Pulse Wave Velocity
Case-Control Studies
Cross-Sectional Studies
Diastole
Echocardiography, Doppler
Female
Humans
Male
Middle Aged
Peripheral Arterial Disease/diagnosis
Predictive Value of Tests
Risk Factors
Time Factors
Vascular Stiffness
Ventricular Dysfunction, Left/diagnostic imaging
Ventricular Function, Left

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12265-019-09892-3

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Mokotedi, L., Gunter, S., Robinson, C., Michel, F., Solomon, A., Norton, G. R., Woodiwiss, A. J., Tsang, L., Dessein, P. H., & Millen, A. M. E. (2019). Early Wave Reflection and Pulse Wave Velocity Are Associated with Diastolic Dysfunction in Rheumatoid Arthritis. Journal of Cardiovascular Translational Research, 12(6), 580-590. https://doi.org/10.1007/s12265-019-09892-3

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abstract = "Rheumatoid arthritis (RA) impacts arterial and diastolic function. This study examined whether arterial properties can determine diastolic function in RA. In 173 RA patients, arterial function measures including carotid femoral pulse wave velocity (PWV), central systolic and pulse pressure, pulse pressure amplification, and the magnitude and timing of the forward and reflected waves were measured using applanation tonometry. Diastolic function parameters including the ratio of early-to-late transmitral velocity (E/A) and ratio of E to the mean of the lateral and septal wall myocardial tissue lengthening (e') were measured using echocardiography. The timing of the reflected wave was associated with E/A; PWV was related to E/e'. The timing of the reflected wave, forward wave magnitude, and pulse pressure amplification were associated with impaired relaxation; PWV was related to increased left ventricular (LV) filling pressure. Early wave reflection and PWV are associated with LV-impaired relaxation and increased filling pressure, respectively, in RA.",

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author = "Lebogang Mokotedi and Sul{\'e} Gunter and Chanel Robinson and Frederic Michel and Ahmed Solomon and Norton, {Gavin R} and Woodiwiss, {Angela J} and Linda Tsang and Dessein, {Patrick H} and Millen, {Aletta M E}",

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AU - Mokotedi, Lebogang

AU - Gunter, Sulé

AU - Robinson, Chanel

AU - Michel, Frederic

AU - Solomon, Ahmed

AU - Norton, Gavin R

AU - Woodiwiss, Angela J

AU - Tsang, Linda

AU - Dessein, Patrick H

AU - Millen, Aletta M E

PY - 2019/12

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N2 - Rheumatoid arthritis (RA) impacts arterial and diastolic function. This study examined whether arterial properties can determine diastolic function in RA. In 173 RA patients, arterial function measures including carotid femoral pulse wave velocity (PWV), central systolic and pulse pressure, pulse pressure amplification, and the magnitude and timing of the forward and reflected waves were measured using applanation tonometry. Diastolic function parameters including the ratio of early-to-late transmitral velocity (E/A) and ratio of E to the mean of the lateral and septal wall myocardial tissue lengthening (e') were measured using echocardiography. The timing of the reflected wave was associated with E/A; PWV was related to E/e'. The timing of the reflected wave, forward wave magnitude, and pulse pressure amplification were associated with impaired relaxation; PWV was related to increased left ventricular (LV) filling pressure. Early wave reflection and PWV are associated with LV-impaired relaxation and increased filling pressure, respectively, in RA.

AB - Rheumatoid arthritis (RA) impacts arterial and diastolic function. This study examined whether arterial properties can determine diastolic function in RA. In 173 RA patients, arterial function measures including carotid femoral pulse wave velocity (PWV), central systolic and pulse pressure, pulse pressure amplification, and the magnitude and timing of the forward and reflected waves were measured using applanation tonometry. Diastolic function parameters including the ratio of early-to-late transmitral velocity (E/A) and ratio of E to the mean of the lateral and septal wall myocardial tissue lengthening (e') were measured using echocardiography. The timing of the reflected wave was associated with E/A; PWV was related to E/e'. The timing of the reflected wave, forward wave magnitude, and pulse pressure amplification were associated with impaired relaxation; PWV was related to increased left ventricular (LV) filling pressure. Early wave reflection and PWV are associated with LV-impaired relaxation and increased filling pressure, respectively, in RA.

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KW - Female

KW - Humans

KW - Male

KW - Middle Aged

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KW - Time Factors

KW - Vascular Stiffness

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KW - Ventricular Function, Left

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Early Wave Reflection and Pulse Wave Velocity Are Associated with Diastolic Dysfunction in Rheumatoid Arthritis

Abstract

Keywords

UN SDGs

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