Effects of high salt-Low potassium diet on blood pressure and vascular reactivity in male sprague dawley rats

Lebogang Mokotedi, Frederic S. Michel, Angela J. Woodiwiss, Gavin R. Norton, Aletta M.E. Millen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Sodium (Na + ) intake increases vascular reactivity. Whether low potassium (K + ) intake affects vascular reactivity–associated blood pressure (BP) changes is uncertain. This study aimed to determine whether Na + -induced increases in BP and vascular reactivity are altered by low K + intake. Male Sprague Dawley rats were assigned to 3 dietary groups for 6 weeks: a standard Na + K + diet (control, n = 12), a high Na + -normal K + diet (HS-NormK, n = 12), and a high Na + -low K + diet (HS-LowK, n = 12). BP was measured at baseline and after the dietary intervention. Na + and K + excretions and vascular reactivity were measured after the dietary intervention. The Na + /K + ratio was significantly higher in the HS-LowK compared with the other groups. Systolic and diastolic BPs increased significantly in the HS-NormK and HS-LowK groups. In mesenteric arteries, the dose–response curves for phenylephrine-induced contractions shifted to the left and the EC 50 (mean 6 SD) was significantly lower in the HS-NormK (0.51 6 0.17 mM, P = 0.003) and HS-LowK (0.69 6 0.14 mM, P = 0.005) groups compared with the control (3.24 6 0.79 mM). Systolic (r = 20.58 P = 0.002) and diastolic (r = 20.61 P = 0.001) BPs were associated with the EC 50 of phenylephrine-induced contraction in mesenteric arteries. High Na + intake induces increased alpha-1 receptor responsiveness in mesenteric arteries, which may be responsible for the increase in BP and is not affected by low dietary K + intake.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Issue number6
Publication statusPublished - 2018
Externally publishedYes


  • Blood pressure
  • Potassium intake
  • Sodium intake
  • Vascular reactivity


Dive into the research topics of 'Effects of high salt-Low potassium diet on blood pressure and vascular reactivity in male sprague dawley rats'. Together they form a unique fingerprint.

Cite this