TY - JOUR
T1 - Ellisras Longitudinal Study 2017: Elevated serum levels of carboxymethyl-lysine, an advanced glycation end-product, are associated with higher odds of developing endothelial dysfunction in black South African patients with type 2 diabetes mellitus (ELS 29)
T2 - Elevated serum levels of carboxymethyl-lysine, an advanced glycation end-product, are associated with higher odds of developing endothelial dysfunction in black South African patients with type 2 diabetes mellitus (ELS 29)
AU - Mogale, Mototelo Alfred
AU - Mhlanga, Catherine Martha
AU - Gololo, Sechene Stanley
AU - Adu, Augustine
N1 - Funding Information:
We acknowledge the contribution of the nursing and medical personnel as well as the phlebotomists at the diabetes clinic of Dr George Mukhari Academic Hospital. We are grateful for the research funding obtained from the National Research Foundation (grant no. TP1407187704).
Publisher Copyright:
© 2019 Clinics Cardive Publishing (PTY)Ltd. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2019 Clinics Cardive Publishing (PTY)Ltd. All rights reserved. This case-control study investigated the association between major types of serum advanced glycation end-products (AGEs) and selected serum/plasma markers of endothelial dysfunction in black patients with type 2 diabetes mellitus at Dr George Mukhari Academic Hospital. Serum AGEs were measured using either enzyme-linked immunosorbent assay (ELISA) or spectrofluoremetry. Serum markers of endothelial dysfunction were measured using either ELISA or calometry. The correlation and associations between major types of serum AGEs and markers of endothelial dysfunction were investigated using the Spearman correlation coefficient and bivariate logistic regression analysis, respectively. Although both serum total immunogenic AGEs and serum carboxymethyl-lysine (CML) were moderately and negatively associated with endothelial dysfunction, only serum CML was significantly associated with a higher odds for the development of endothelial dysfunction (low nitric oxide levels) in our diabetic subjects. It can therefore be concluded from this study that high serum levels of CML may predispose to endothelial dysfunction in black South Africans with type 2 diabetes.
AB - © 2019 Clinics Cardive Publishing (PTY)Ltd. All rights reserved. This case-control study investigated the association between major types of serum advanced glycation end-products (AGEs) and selected serum/plasma markers of endothelial dysfunction in black patients with type 2 diabetes mellitus at Dr George Mukhari Academic Hospital. Serum AGEs were measured using either enzyme-linked immunosorbent assay (ELISA) or spectrofluoremetry. Serum markers of endothelial dysfunction were measured using either ELISA or calometry. The correlation and associations between major types of serum AGEs and markers of endothelial dysfunction were investigated using the Spearman correlation coefficient and bivariate logistic regression analysis, respectively. Although both serum total immunogenic AGEs and serum carboxymethyl-lysine (CML) were moderately and negatively associated with endothelial dysfunction, only serum CML was significantly associated with a higher odds for the development of endothelial dysfunction (low nitric oxide levels) in our diabetic subjects. It can therefore be concluded from this study that high serum levels of CML may predispose to endothelial dysfunction in black South Africans with type 2 diabetes.
KW - Black South Africans
KW - Endothelial dysfunction
KW - Markers of endothelial dysfunction
KW - Serum AGEs
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85072509471&partnerID=8YFLogxK
U2 - 10.5830/CVJA-2018-060
DO - 10.5830/CVJA-2018-060
M3 - Article
C2 - 31469381
SN - 1995-1892
VL - 30
SP - 193
EP - 197
JO - Cardiovascular Journal of Africa
JF - Cardiovascular Journal of Africa
IS - 4
ER -