TY - JOUR
T1 - Emergence and characterization of serotype G9 rotavirus strains from africa
AU - Page, Nicola
AU - Esona, Mathew
AU - Armah, George
AU - Nyangao, James
AU - Mwenda, Jason
AU - Sebunya, Theresa
AU - Basu, Gorav
AU - Pyndiah, Naidu
AU - Potgieter, Natasha
AU - Geyer, Annelise
AU - Steele, A. Duncan
N1 - Funding Information:
Financial support: South African Medical Research Council, the Poliomyelitis Research Foundation, and the Paul and Stella Loewenstein Doctoral Scholarship (to N.P.). Potential conflicts of interest: none reported.
Funding Information:
Supplement sponsorship: This article is part of a supplement entitled “Rotavirus Infection in Africa: Epidemiology, Burden of Disease, and Strain Diversity,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership among PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Serotype G9 strains have been detected sporadically and in localized outbreaks in various African countries, including South Africa, Botswana, Malawi, Kenya, Cameroon, Nigeria, Ghana, Guinea-Bissau, Libya, and Mauritius. Serotype G9 strains were analyzed to investigate genogroup characteristics, including subgroup specificity, electropherotype, and P and G genotypes. In addition, the antigenic composition of the South African G9 strains was assessed. African G9 strains were associated with both DS-1-like characteristics and Wa-like characteristics, indicating the predisposition of G9 strains to frequently reassort. Despite these reassortment events, serotype G9 strains appear to maintain antigenic character in the outer capsid protein, as evident with the reaction of the South African G9 strains with the G9-specific monoclonal antibody F45:1. Phylogenetic analysis clustered African G9 strains geographically, regardless of genogroup characteristics, into 1 lineage (IIId). Two groups of G9 strains, originating in India and Japan, were identified in this lineage. Continuous surveillance of circulating rotavirus strains in Africa is vital to prepare for future vaccine implementation on a continent that clearly needs such preventative medicines.
AB - Serotype G9 strains have been detected sporadically and in localized outbreaks in various African countries, including South Africa, Botswana, Malawi, Kenya, Cameroon, Nigeria, Ghana, Guinea-Bissau, Libya, and Mauritius. Serotype G9 strains were analyzed to investigate genogroup characteristics, including subgroup specificity, electropherotype, and P and G genotypes. In addition, the antigenic composition of the South African G9 strains was assessed. African G9 strains were associated with both DS-1-like characteristics and Wa-like characteristics, indicating the predisposition of G9 strains to frequently reassort. Despite these reassortment events, serotype G9 strains appear to maintain antigenic character in the outer capsid protein, as evident with the reaction of the South African G9 strains with the G9-specific monoclonal antibody F45:1. Phylogenetic analysis clustered African G9 strains geographically, regardless of genogroup characteristics, into 1 lineage (IIId). Two groups of G9 strains, originating in India and Japan, were identified in this lineage. Continuous surveillance of circulating rotavirus strains in Africa is vital to prepare for future vaccine implementation on a continent that clearly needs such preventative medicines.
UR - http://www.scopus.com/inward/record.url?scp=77955668308&partnerID=8YFLogxK
U2 - 10.1086/653551
DO - 10.1086/653551
M3 - Article
C2 - 20684719
AN - SCOPUS:77955668308
SN - 0022-1899
VL - 202
SP - S55-S63
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - SUPPL. 1
ER -
