Evaluation of rotavirus vaccines in Asia-Are there lessons to be learnt?

R. Mirzayeva, A. D. Steele*, U. D. Parashar, K. Zaman, K. M. Neuzil, E. A.S. Nelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Rotavirus mortality is highest in the Asia-Pacific region and rotavirus vaccines could have enormous impact here. Yet, live-attenuated orally administered rotavirus vaccines have been evaluated in a small number of immunogenicity studies in some Asian countries, where the immune responses have been documented to be moderate in low-income countries with high diarrhoeal disease burden and mortality, and high in middle-/high-income countries with little reported rotavirus deaths. This review of these rotavirus clinical trials examines the results observed and attempts to draw lessons to inform decision-making, aid design of additional clinical trials and guide vaccine development by local manufacturers.

Original languageEnglish
Pages (from-to)F120-F129
Issue numberSUPPL. 5
Publication statusPublished - 20 Nov 2009
Externally publishedYes


  • Clinical trials
  • Rotavirus
  • Vaccines


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