TY - JOUR
T1 - Facial skin-lightening benefits of the tetrapeptide Pro-Lys-Glu-Lys on subjects with skin types V-VI living in South Africa
AU - Farwick, Mike
AU - Maczkiewitz, Ursula
AU - Lersch, Peter
AU - Summers, Beverley
AU - Rawlings, Anthony V.
PY - 2011/9
Y1 - 2011/9
N2 - Background Irregular skin pigmentation may be a substantial contributor to the signs of aging and to a person's lack of psychological well-being. Although a large number of skin-lightening agents are available, the opportunity exists to identify more efficacious agents, agents that target alternative biological mechanisms. Aims To provide clinical evidence of the skin-lightening effect of the tetrapeptide, Pro-Lys-Glu-Lys (PKEK), on subjects with skin types V-VI living in South Africa. Methods Pro-Lys-Glu-Lys was evaluated in a double-blind and vehicle-controlled clinical study using expert grading of digital images by comparing its effects in subjects with skin types V-VI suffering from facial melasma and postinflammatory hyperpigmentation. Results This study demonstrated the efficacy of PKEK on subjects with skin types V-VI. On comparing the two treatments, the skin-lightening peptide-containing formulation was significantly superior to the vehicle at 12weeks on overall appearance (P<0.05) and evenness of skin tone (P<0.01). Conclusions The tetrapeptide, PKEK, has proven skin-lightening benefits on skin discoloration from melasma and postinflammatory hyperpigmentation. These studies have been conducted on subjects with skin types V-VI living in South Africa, but we believe this technology to be suitable for all racial groups.
AB - Background Irregular skin pigmentation may be a substantial contributor to the signs of aging and to a person's lack of psychological well-being. Although a large number of skin-lightening agents are available, the opportunity exists to identify more efficacious agents, agents that target alternative biological mechanisms. Aims To provide clinical evidence of the skin-lightening effect of the tetrapeptide, Pro-Lys-Glu-Lys (PKEK), on subjects with skin types V-VI living in South Africa. Methods Pro-Lys-Glu-Lys was evaluated in a double-blind and vehicle-controlled clinical study using expert grading of digital images by comparing its effects in subjects with skin types V-VI suffering from facial melasma and postinflammatory hyperpigmentation. Results This study demonstrated the efficacy of PKEK on subjects with skin types V-VI. On comparing the two treatments, the skin-lightening peptide-containing formulation was significantly superior to the vehicle at 12weeks on overall appearance (P<0.05) and evenness of skin tone (P<0.01). Conclusions The tetrapeptide, PKEK, has proven skin-lightening benefits on skin discoloration from melasma and postinflammatory hyperpigmentation. These studies have been conducted on subjects with skin types V-VI living in South Africa, but we believe this technology to be suitable for all racial groups.
KW - Peptide
KW - Photoaging
KW - Proline attached to its N-terminus
KW - Proopiomelanocortin
KW - Skin-lightening
KW - α-melanocyte-stimulating hormone
UR - http://www.scopus.com/inward/record.url?scp=80052440324&partnerID=8YFLogxK
U2 - 10.1111/j.1473-2165.2011.00569.x
DO - 10.1111/j.1473-2165.2011.00569.x
M3 - Article
C2 - 21896134
AN - SCOPUS:80052440324
SN - 1473-2130
VL - 10
SP - 217
EP - 223
JO - Journal of Cosmetic Dermatology
JF - Journal of Cosmetic Dermatology
IS - 3
ER -