First-in-human infection imaging with ⁸⁹Zr-labelled leukocytes and comparison of scan quality with [^99mTc]Tc-HMPAO-labelled leukocytes

Keyphrases

• Technetium-99m 100%
• Human Infection 100%
• Labeled Leukocytes 100%
• Zirconium-89 (89Zr) 100%
• Infection Imaging 100%
• Scan Quality 100%
• First-in-human 100%
• HMPAO 100%
• Leukocytes 25%
• Single-photon Emission Computed Tomography (SPECT) 18%
• Positron Emission Tomography 18%
• Biodistribution 18%
• Leukocyte Labeling 18%
• Labeling Efficiency 12%
• Whole-body 12%
• First-in-human Study 12%
• Nuclear Medicine 6%
• Infection Focus 6%
• Healthy Volunteers 6%
• Standardized Method 6%
• Whole Blood Sample 6%
• Computed Tomography Images 6%
• Osteomyelitis 6%
• White Blood Cell Count 6%
• Tomography Image 6%
• Labeling Approach 6%
• High Cell Viability 6%
• Positron Emission tomography-CT 6%
• Pulmonary Pathology 6%
• Desferrioxamine 6%
• Positron Emitters 6%
• Biological Half-life 6%
• In Vivo Stability 6%
• Single-photon Emission Computed Tomography Imaging 6%
• Oxime 6%
• Oxine 6%
• Intact Cells 6%
• Pathological Uptake 6%
• High Quality Images 6%
• Bifunctional Chelating Agent 6%
• Radiolabeling Methods 6%
• Cell Surface Labeling 6%

Pharmacology, Toxicology and Pharmaceutical Science

• Infection 100%
• Technetium 99m 100%
• Zirconium 89 100%
• Biodistribution 17%
• Human Study 11%
• Normal Human 5%
• Osteomyelitis 5%
• 8 Quinolinol 5%
• Chelating Agent 5%
• Deferoxamine 5%
• Biological Half-Life 5%
• Oxime 5%

Immunology and Microbiology

• Leukocyte 100%
• Single Photon Emission Computed Tomography 18%
• Positron Emission Tomography 13%
• Normal Human 4%
• Isotope Labeling 4%
• Cell Surface 4%
• Image Quality 4%
• Leukocyte Count 4%
• Positron 4%
• Whole Body PET 4%