TY - JOUR
T1 - Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis
AU - Gous, Andries
AU - Lipman, Jeffrey
AU - Scribante, Juan
AU - Tshukutsoane, Shephelia
AU - Hon, Hubert
AU - Pinder, Mary
AU - Mathivha, Rudo
AU - Verhoef, Lia
AU - Stass, Heino
N1 - Funding Information:
The authors thank Bayer (PTY) Ltd (South Africa) for financial support and Bayer AG Germany for ciprofloxacin assays.
PY - 2005/7
Y1 - 2005/7
N2 - This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400 mg every 8 h infused over 60 min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.
AB - This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400 mg every 8 h infused over 60 min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.
KW - Antibiotics
KW - Fluoroquinolone
KW - Intensive Care Unit
KW - Pharmacokinetics
KW - Volume of distribution
UR - http://www.scopus.com/inward/record.url?scp=20744450631&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2005.04.005
DO - 10.1016/j.ijantimicag.2005.04.005
M3 - Article
C2 - 15955670
AN - SCOPUS:20744450631
SN - 0924-8579
VL - 26
SP - 50
EP - 55
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 1
ER -