Fractional-order modelling and analysis of diabetes mellitus: Utilizing the Atangana-Baleanu Caputo (ABC) operator

Pooja Yadav, Shah Jahan*, Kamal Shah, Olumuyiwa James Peter, Thabet Abdeljawad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


This article aims to introduce and analyze a diabetes mellitus model of fractional order, utilizing the ABC derivative. Diabetes mellitus is a prevalent and significant disease worldwide, ranking among the top causes of mortality. It is characterized by chronic metabolic dysfunction, leading to elevated blood glucose levels and subsequent damage to vital organs including the nerves, kidneys, eyes, blood vessels, and heart. The fractional ABC derivative is used in this study to describe and analyze diabetes mellitus mathematically while removing hereditary influences. The investigation begins by exploring the initial points of the diabetes mellitus model. Under the fractional ABC operator, Picard's theorem is used to prove the existence and uniqueness of solutions. For the numerical approximation of solutions in the fractional-order diabetes mellitus model, this study used a specialized technique that combines the principles of fractional calculus and a two-step Lagrange polynomial interpolation. Finally, the obtained results are visually presented through graphical representations, serving as empirical evidence to support our theoretical findings. The numerical experiments showed that the proportion of patients with diabetes mellitus increased as the fractional dimension (θ) reduced. The combination of mathematical modelling, analysis, and numerical simulations provides insights into the dynamics of diabetes mellitus, offering valuable contributions to the understanding and management of this prevalent disease. Additionally, the proposed scheme can be enhanced by incorporating the ABC operator, allowing for the simulation of real-world dynamics and behavior in the coexistence of diabetes mellitus and tuberculosis.

Original languageEnglish
Pages (from-to)200-209
Number of pages10
JournalAlexandria Engineering Journal
Publication statusPublished - 15 Oct 2023
Externally publishedYes


  • Atangana-Baleanu-Caputo operator
  • Existence and uniqueness
  • Fixed point theory
  • Fractional order diabetes mellitus
  • Numerical simulation


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