TY - JOUR
T1 - Gender differences in VLDL1 and VLDL2 triglyceride kinetics and fatty acid kinetics in obese postmenopausal women and obese men
AU - Sarac, Ivana
AU - Backhouse, Katharine
AU - Shojaee-Moradie, Fariba
AU - Stolinski, Michael
AU - Robertson, M. Denise
AU - Bell, Jimmy D.
AU - Thomas, E. Louise
AU - Hovorka, Roman
AU - Wright, John
AU - Umpleby, A. Margot
PY - 2012/7
Y1 - 2012/7
N2 - Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol inwomen.Thismaybe due to gender differences in very-low-density lipoprotein 1 (VLDL1)- and VLDL2-TG and fatty acid kinetics. Objective: Our objective was to investigate whether there are differences in VLDL1- and VLDL2-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease. Research Design and Methods: Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL1-TG and VLDL2-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging. Participants: Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG. Results: Thewomenhad lower visceral fat and higher sc fat than themen(P<0.001 and P<0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P <0.03). VLDL 2-TG PR corrected for fat-free mass was higher in the women (P<0.001). VLDL2-TG and VLDL2-cholesterol pools were higher in the women (P < 0.001 and P < 0.008). VLDL1-TG FCR and PR and VLDL2-TG FCR were not different between genders. Conclusion: Fatty acid and VLDL2-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels.
AB - Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol inwomen.Thismaybe due to gender differences in very-low-density lipoprotein 1 (VLDL1)- and VLDL2-TG and fatty acid kinetics. Objective: Our objective was to investigate whether there are differences in VLDL1- and VLDL2-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease. Research Design and Methods: Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL1-TG and VLDL2-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging. Participants: Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG. Results: Thewomenhad lower visceral fat and higher sc fat than themen(P<0.001 and P<0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P <0.03). VLDL 2-TG PR corrected for fat-free mass was higher in the women (P<0.001). VLDL2-TG and VLDL2-cholesterol pools were higher in the women (P < 0.001 and P < 0.008). VLDL1-TG FCR and PR and VLDL2-TG FCR were not different between genders. Conclusion: Fatty acid and VLDL2-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels.
UR - http://www.scopus.com/inward/record.url?scp=84863586988&partnerID=8YFLogxK
U2 - 10.1210/jc.2011-3248
DO - 10.1210/jc.2011-3248
M3 - Article
C2 - 22508714
AN - SCOPUS:84863586988
SN - 0021-972X
VL - 97
SP - 2475
EP - 2481
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 7
ER -
