Genetic analysis of the near full-length genome of an HIV type 1 A1/C unique recombinant form from northern South Africa

Benson C. Iweriebor, Pascal O. Bessong*, Lufuno G. Mavhandu, Tracy M. Masebe, Julius Nwobegahay, Sylvester R. Moyo, Jeffrey M. Mphahlele

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype C and intersubtype recombinant viruses. This report presents the genetic analysis of a unique recombinant variant from northern South Africa comprised exclusively of subsubtype A1 and subtype C parental viruses. Boot scanning analysis of the near full-length genome with the jumping profile Hidden Markov Model revealed a genomic arrangement with seven breakpoints of recombination alternating between subsubtype A1 and subtype C. Apparently, this is the first report of a unique HIV-1 A1/C recombinant form from northern South Africa and probably the fifth from South Africa. The epidemiologic implication of this variant is unknown.

Original languageEnglish
Pages (from-to)911-915
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume27
Issue number8
DOIs
Publication statusPublished - 1 Aug 2011
Externally publishedYes

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