Genetic analysis of the near full-length genome of an HIV type 1 A1/C unique recombinant form from northern South Africa

Benson C. Iweriebor; Pascal O. Bessong; Lufuno G. Mavhandu; Tracy M. Masebe; Julius Nwobegahay; Sylvester R. Moyo; Jeffrey M. Mphahlele

doi:10.1089/aid.2010.0286

Genetic analysis of the near full-length genome of an HIV type 1 A1/C unique recombinant form from northern South Africa

Benson C. Iweriebor
, Pascal O. Bessong^*
, Lufuno G. Mavhandu
, Tracy M. Masebe
, Julius Nwobegahay
, Sylvester R. Moyo
, Jeffrey M. Mphahlele

^*Corresponding author for this work

Virological Pathology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype C and intersubtype recombinant viruses. This report presents the genetic analysis of a unique recombinant variant from northern South Africa comprised exclusively of subsubtype A1 and subtype C parental viruses. Boot scanning analysis of the near full-length genome with the jumping profile Hidden Markov Model revealed a genomic arrangement with seven breakpoints of recombination alternating between subsubtype A1 and subtype C. Apparently, this is the first report of a unique HIV-1 A1/C recombinant form from northern South Africa and probably the fifth from South Africa. The epidemiologic implication of this variant is unknown.

Original language	English
Pages (from-to)	911-915
Number of pages	5
Journal	AIDS Research and Human Retroviruses
Volume	27
Issue number	8
DOIs	https://doi.org/10.1089/aid.2010.0286
Publication status	Published - 1 Aug 2011

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abstract = "Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype C and intersubtype recombinant viruses. This report presents the genetic analysis of a unique recombinant variant from northern South Africa comprised exclusively of subsubtype A1 and subtype C parental viruses. Boot scanning analysis of the near full-length genome with the jumping profile Hidden Markov Model revealed a genomic arrangement with seven breakpoints of recombination alternating between subsubtype A1 and subtype C. Apparently, this is the first report of a unique HIV-1 A1/C recombinant form from northern South Africa and probably the fifth from South Africa. The epidemiologic implication of this variant is unknown.",

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AU - Iweriebor, Benson C.

AU - Bessong, Pascal O.

AU - Mavhandu, Lufuno G.

AU - Masebe, Tracy M.

AU - Nwobegahay, Julius

AU - Moyo, Sylvester R.

AU - Mphahlele, Jeffrey M.

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N2 - Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype C and intersubtype recombinant viruses. This report presents the genetic analysis of a unique recombinant variant from northern South Africa comprised exclusively of subsubtype A1 and subtype C parental viruses. Boot scanning analysis of the near full-length genome with the jumping profile Hidden Markov Model revealed a genomic arrangement with seven breakpoints of recombination alternating between subsubtype A1 and subtype C. Apparently, this is the first report of a unique HIV-1 A1/C recombinant form from northern South Africa and probably the fifth from South Africa. The epidemiologic implication of this variant is unknown.

AB - Human immunodeficiency virus type 1 (HIV-1) has a high propensity for recombination. The epidemic in South Africa is predominantly driven by HIV-1 subtype C with occasional description of non-subtype C and intersubtype recombinant viruses. This report presents the genetic analysis of a unique recombinant variant from northern South Africa comprised exclusively of subsubtype A1 and subtype C parental viruses. Boot scanning analysis of the near full-length genome with the jumping profile Hidden Markov Model revealed a genomic arrangement with seven breakpoints of recombination alternating between subsubtype A1 and subtype C. Apparently, this is the first report of a unique HIV-1 A1/C recombinant form from northern South Africa and probably the fifth from South Africa. The epidemiologic implication of this variant is unknown.

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DO - 10.1089/aid.2010.0286

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JF - AIDS Research and Human Retroviruses

IS - 8

ER -

Genetic analysis of the near full-length genome of an HIV type 1 A1/C unique recombinant form from northern South Africa

Abstract

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