Global impact of rotavirus vaccines

Jacqueline E. Tate, Manish M. Patel, A. Duncan Steele, Jon R. Gentsch, Daniel C. Payne, Margaret M. Cortese, Osamu Nakagomi, Nigel A. Cunliffe, Baoming Jiang, Kathleen M. Neuzil, Lucia H. De Oliveira, Roger I. Glass, Umesh D. Parashar

Research output: Contribution to journalReview articlepeer-review

84 Citations (Scopus)

Abstract

The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been observed. Besides protecting vaccinated children, disease rates also appear to be reduced in unvaccinated children, suggesting indirect benefits from vaccination (i.e., herd protection). Early clinical trial data from Africa and Asia are promising, and further efforts are needed to optimize the benefits of vaccination in developing countries where vaccines are likely to have their greatest impact.

Original languageEnglish
Pages (from-to)395-407
Number of pages13
JournalExpert Review of Vaccines
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2010
Externally publishedYes

Keywords

  • Diarrhea
  • Rotavirus
  • Rotavirus vaccination
  • Vaccine effectiveness

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