HIV-associated Kaposi sarcoma: pathogenic mechanisms

Liviu Feller; Neil H. Wood; Johan Lemmer

doi:10.1016/j.tripleo.2006.08.015

HIV-associated Kaposi sarcoma: pathogenic mechanisms

Liviu Feller^*
, Neil H. Wood
, Johan Lemmer

^*Corresponding author for this work

Periodontology and Oral Medicine

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Kaposi sarcoma (KS) is a multicentric angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema. Human herpesvirus (HHV)-8, a gamma-herpesvirus, is a critical factor, but is not alone sufficient for the initiation of KS. Other cofactors such as human immunodeficiency virus (HIV), host-derived cytokines, chemokines, and growth factors are required for the development of KS. Whether HIV-associated KS is a reactive hyperplastic inflammatory lesion or a true neoplasm is still controversial. It is likely that HIV-associated KS begins as a reactive disorder that in some cases progresses to a monoclonal, an oligoclonal, and a polyclonal neoplasm.

Original language	English
Pages (from-to)	521-529
Number of pages	9
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume	104
Issue number	4
DOIs	https://doi.org/10.1016/j.tripleo.2006.08.015
Publication status	Published - Oct 2007

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SDG 3 Good Health and Well-being

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10.1016/j.tripleo.2006.08.015

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title = "HIV-associated Kaposi sarcoma: pathogenic mechanisms",

abstract = "Kaposi sarcoma (KS) is a multicentric angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema. Human herpesvirus (HHV)-8, a gamma-herpesvirus, is a critical factor, but is not alone sufficient for the initiation of KS. Other cofactors such as human immunodeficiency virus (HIV), host-derived cytokines, chemokines, and growth factors are required for the development of KS. Whether HIV-associated KS is a reactive hyperplastic inflammatory lesion or a true neoplasm is still controversial. It is likely that HIV-associated KS begins as a reactive disorder that in some cases progresses to a monoclonal, an oligoclonal, and a polyclonal neoplasm.",

author = "Liviu Feller and Wood, \{Neil H.\} and Johan Lemmer",

year = "2007",

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doi = "10.1016/j.tripleo.2006.08.015",

language = "English",

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journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics",

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TY - JOUR

T1 - HIV-associated Kaposi sarcoma

T2 - pathogenic mechanisms

AU - Feller, Liviu

AU - Wood, Neil H.

AU - Lemmer, Johan

PY - 2007/10

Y1 - 2007/10

N2 - Kaposi sarcoma (KS) is a multicentric angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema. Human herpesvirus (HHV)-8, a gamma-herpesvirus, is a critical factor, but is not alone sufficient for the initiation of KS. Other cofactors such as human immunodeficiency virus (HIV), host-derived cytokines, chemokines, and growth factors are required for the development of KS. Whether HIV-associated KS is a reactive hyperplastic inflammatory lesion or a true neoplasm is still controversial. It is likely that HIV-associated KS begins as a reactive disorder that in some cases progresses to a monoclonal, an oligoclonal, and a polyclonal neoplasm.

AB - Kaposi sarcoma (KS) is a multicentric angioproliferative disorder characterized by spindle cell proliferation, neo-angiogenesis, inflammation, and edema. Human herpesvirus (HHV)-8, a gamma-herpesvirus, is a critical factor, but is not alone sufficient for the initiation of KS. Other cofactors such as human immunodeficiency virus (HIV), host-derived cytokines, chemokines, and growth factors are required for the development of KS. Whether HIV-associated KS is a reactive hyperplastic inflammatory lesion or a true neoplasm is still controversial. It is likely that HIV-associated KS begins as a reactive disorder that in some cases progresses to a monoclonal, an oligoclonal, and a polyclonal neoplasm.

UR - https://www.scopus.com/pages/publications/34648825062

U2 - 10.1016/j.tripleo.2006.08.015

DO - 10.1016/j.tripleo.2006.08.015

M3 - Article

C2 - 17142074

AN - SCOPUS:34648825062

SN - 1079-2104

VL - 104

SP - 521

EP - 529

JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics

IS - 4

ER -

HIV-associated Kaposi sarcoma: pathogenic mechanisms

Abstract

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